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I am excited to share my TED Talks at #TED2022 on how lab-grown neural cells and circuits can contribute to reverse engineering human brain development & uncover the biology of neuropsychiatric disorders ted.com/talks/sergiu_p… #assembloids #organoids #brain #Mentalhealth

Hundreds of genes have been associated with autism & neurodev disorders But how do these genes impact specific stages in human development? In a new preprint, Xiangling Meng took a bold approach & developed CRISPR screens in #assembloids to map 425 genes on interneuron dev stages 👇

Congratulations to Dr. Huda Zoghbi who was presented the prestigious The Kavli Prize in Oslo, Norway for her contributions in the field of neuroscience. His Majesty King Harald V presided over the awards ceremony where 11 laureates were honored. Learn more: ms.spr.ly/6019jxJgU

🧠We are hiring! Are you a recent PhD grad 🎓👩‍🔬 with interests in #Parkinsons #ALS #Neurodegeneration #Mousemodels #Synuclein #TDP43? Join our vibrant team! We are actively seeking out postdocs to work on some really exciting projects in the lab. Please share broadly/RT!

Congratulations, Dr. H Zoghbi, for receiving the 2022 Elaine Redding Brinster Prize Award for her work pinpointing the genetic causes of a pair of devastating #neurologicalDiseases BCMHouston TCHResearchNews BCM Department of Neuroscience BCM Department of Medicine pennmedicine.org/news/news-rele… Penn Medicine

Check out a new paper from our lab about the nomenclature of human cellular model of nervous system

Check out this great opportunity if you want to work with brain organoids but don’t know where to start with

Today is a great day for my lab. Our paper (before proof correction) has been published in Journal of Clinical Investigation! Meningeal dendritic cells drive neuropathic pain through elevation of the kynurenine metabolic pathway in mice jci.org/articles/view/…

Nature research paper: Maturation and circuit integration of transplanted human cortical organoids go.nature.com/3RYyTDw

Congratulations Li Wang Beautiful work

Delighted that our nature consensus article on #organoids #assembloids #transplantation is now open access! Grateful for our incredible working group and hopeful that this short piece covering nomenclature & misconceptions will reach more readers nature.com/articles/s4158…

"We have a longer and longer list of genes associated with [autism], and we need to find a way of mapping or grouping them to see what processes they impact," says Sergiu P. Pasca. By Isabel Ruehl. bioRxiv: bit.ly/3VAdoes bit.ly/3uwO4dT

Latest lab group photo. Proud of these science champions!

I am presenting two posters at the coming SFN. Please stop by if you are interested in combining CRISPR screening and brain organoids to study Autism or using brain organoids to study neuromodulation.

RT

Today, I’m thrilled have our lab’s work featured on the cover of nature In this article, we have developed a therapeutic approach for a severe condition called Timothy syndrome. This has been a long journey. It started with making hiPS cell-derived neurons in 2D cultures 15

In our nature paper published last week, we identified a potential therapeutic for Timothy Syndrome (TS) using human neural #organoids, #assembloids and neurons from TS patients transplanted into rats. Here’s a more detailed description of what we found 👇