🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

#IL10power! Another example of #autoantibodies that cause a primary immune deficiency-like disease! NEJM a paper shows that anti-IL10 antibodies cause #IBD that can be cured by getting rid of (autoreactive) B cells! nejm.org/doi/full/10.10…

Our recent work, Dr. Wenjing Ying, a fantastic pediatrician, reports epidermodysplasia verruciformis in a STK4 deficient case from UTSW, despite CD4+ T lymphopenia, expanded Vδ2+ γδ-T cells compensate for immune surveillance. link.springer.com/article/10.100… Thanks for Casanova Lab

1/ We are delighted to share our work published in nature today characterizing two patients with inherited complete TNF deficiency and recurrent tuberculosis (nature.com/articles/s4158…).

Congratulations to Zhijian “James” Chen, 2024 #LaskerAward winner! – “for the discovery of the cGAS enzyme that senses foreign and self DNA, solving the mystery of how DNA stimulates immune and inflammatory responses.” laskerfoundation.org/winners/cgas-e… #Lasker2024 #LaskerLaureate

1/ Excited to share our latest publication in PNASNews! We report two patients with autosomal recessive RelB deficiency. Check out the thread for key highlights from our study! 🧵👇doi.org/10.1073/pnas.2…

October is here, and so is #ESID2024! 👉 Breakthroughs in molecular diagnostics and next-gen sequencing are driving new discoveries in inborn errors of immunity. Join top experts in Marseille! 📅 Just 2 weeks left! 16-19 October 2024 🇫🇷 🔗 Register: esidmeeting.org/registration/

An update of LoGoFunc (pathogenic gain-of-function and loss-of-function predictions for all possible human missense variants) has just been generated by David Stein: itanlab.shinyapps.io/goflof/ Fixing some issues with VEP annotations. Thanks to Meltem Ece Kars for testing.

📢Its National Healthcare Quality Week!📢 The American Gastroenterological Association (AGA) #QualityCommittee has been working on exciting tools to help your practice deliver ⭐️High Quality Care⭐️ WE want to know...➡️What does healthcare quality mean to you?

We are looking for a motivated research assistant to work at the intersection of human genetics, immunology and molecular biology at Vanderbilt University Medical Center in Nashville. Interested? Please, apply using the link below. vumc.wd1.myworkdayjobs.com/vumccareers/jo…

Super!

Very excited to see our paper out in Nature Comms. Amazing team!

Our latest publication with #DrHur & #DrKastrinos, Impact of Population Screening for Lynch Syndrome, reveals that Lynch syndrome is not so rare in AllofUsResearch. Clinical penetrance varies: MLH1 > MSH2 > MSH6 > PMS2. UTSW Internal Medicine read more rdcu.be/d5Mse

We’re thrilled to announce our partnership with the International Alliance for Primary Immunodeficiency Societies (#IAPIDS) to launch the Journal of Human Immunity (JHI) Journal of Human Immunity! Stay tuned for groundbreaking, #OpenAccess research on #HumanImmunity! hubs.la/Q032Q5Zt0

1/ We are proud of our former trainees and will be highlighting their accomplishments from time-to-time. First up is Satoshi Okada, appointed Chief Professor of the Department of Pediatrics at Hiroshima University in 2020 and advanced to Head of the Program of Medicine in 2024.

1/_Spotlight on our former trainee - Yuval Itan! With us from 2010-17, Yuval was a post doc in our dry lab, then a research associate, and finally a research associate professor. He is now an associate professor at Icahn School of Medicine, Mt. Sinai and PI at the Itan Lab.

*******JOB ALERT********* Join our team as a Postdoc or Research Assistant investigating the genetic basis of life-threatening infections in children Imperial College London . Apply now 🔗 rb.gy/1c6b3n #ScienceJobs #Postdoc #Immunology #IEI #Humangenetics Imperial Department of Infectious Disease