Out in PNASNews now, we find that the Rag-Ragulator heptamer anchors the GATOR supercomplex to the lysosome. Our results highlight the complex role the Rags play in regulating mTORC1 activation and lysosomal homeostasis (1/2)

In this week’s nature, we report that nutrients do not activate mTORC1 through degradation of GATOR1 component DEPDC5. Other molecular events signal the presence of amino acids to this essential growth pathway! nature.com/articles/s4158…

Seeing is believing! Our sequel now shows precisely how midnolin delivers substrates directly to the proteasome by repurposing established proteasomal subunits, a process critical to suppress multiple myeloma via IRF4 degradation. biorxiv.org/content/10.110…

While working on midnolin, the Susan Shao serendipitously solved a beautiful high-resolution structure of TXNL1 bound to the proteasome. We also show that oxidative stress caused by certain metal/metalloids leads to TXNL1 ubiquitin-independent degradation. biorxiv.org/content/10.110…

Thank you Damon Runyon Cancer Research Foundation for the generous support! Very excited to be one of this year’s Dale F Frey Award for Breakthrough Scientists!

So happy and proud to see our story online!! Thank you, the midnolin team!

A new study in Cell Press led by Dana-Farber’s Xin Gu highlights midnolin as a key regulatory component of proteostasis in plasma cells and suggests that restoring or enhancing this pathway could represent a novel therapeutic avenue in myeloma treatment. Read more:

Super grateful for the generous support from Esther A. & Joseph Klingenstein Fund! We are excited to make more discoveries uncovering the roles of the midnolin-proteasome pathway in neurons!

New online! A heterotrimeric protein complex assembles the metazoan V-ATPase upon dissipation of proton gradients bit.ly/3GjrXRN

Great study from Chris Nardone from Rapoport Lab on organelle pH regulation! He characterized a super cool complex that assembles v-ATPase. Congratulations 🎊🍾🥳

Why do some genetic mutations devastate specific tissues while sparing others? We explore this question in GGC repeat disorders, revealing a mechanism linking protein aggregation to tRNA splicing failure in the brain. 🧵 on our new paper in Science: 🔗 science.org/doi/10.1126/sc…

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Excited to share our latest work onll LZTR1 just published Science Magazine!! A wonderful multidisciplinary collaboration between Simanshu Dhirendra's lab and our lab that provides structural understanding on RAS substrate and nucleotide specificity, and effect of mutations in LZTR1.

Excited to share a new paper and online resource from our lab published today. We developed a mass spectrometry approach that leverages genetic diversity to systematically nominate functional relationships between metabolites and proteins. nature.com/articles/s4158…