A humble attempt to unveil the heterogeneity of mononuclear phagocytes. Cannot wait for the next adventure!

Glad it is officially out in Life Science Alliance!

Chemokine, Metallothionein, Interferon AMs, et al. Geisel School of Medicine at Dartmouth Xin Li Claudia Jakubzick

ScRNA-seq Expression of IFI27 and APOC2 Identifies Four AM Superclusters in Healthy BALF. Geisel School of Medicine at Dartmouth Xin Li Claudia Jakubzick life-science-alliance.org/content/5/11/e…

We've added a new dataset! Come check out how migratory dendritic cell chemokine trails direct monocytes to our lymph nodes and regulate adaptive immunity! Submitted by Xin Li Claudia Jakubzick ln-mono-dc.cells.ucsc.edu

Amazing talks. Thrilled to see my postdocs present their work at the 61st Midwinter Conference for Immunologists. I am hooked! Thank you, Dr. Amanda M Jamieson @amandamjamieson.bsky.social and Deepta Bhattacharya for a fabulous Midwinter Conference of Immunologists meeting!

A privilege to write with Xin Li this preview of Finlay... J Allen’s work in Immunity on Th2 cells control monocyte to TR-macrophage differentiation during nematode infection Macrophages show up in style when Th2 lymphocytes organize their homecoming cell.com/immunity/fullt…

Thank you for this opportunity, Claudia Jakubzick ! It was a pleasure to work on this and learn more about the regulation and function of cavity macrophages! Love everything about macrophages! #MacrophagesRule

Thrilled to share our preprint. Interstitial macs unbiased clustering is due to conserved chemokine expression patterns, resembling T cell biology with cytokines 👇 IM-depleting 🐭showed their major role is orchestrating leukocyte recruitment in TLOs. biorxiv.org/content/10.110…

Excited to have worked with many talented individuals! Great to see this interesting story now out on #bioRxiv. Thank you Claudia Jakubzick for the opportunity to contribute to this important research, which really revolutionized my understanding of the multifaceted roles of #macrophages

Check out this work from Claudia Jakubzick Lab in DMS_MicroImmuno which includes the work of 2 MCB DartGRAD students, Xin Li and Shawn Musial along with Dartmouth colleagues! #macrophages 🧑‍🔬🧪

Macrophage engulfing pathogens 🛡️🦠

Fun fact: we contain ~0.6 kg macrophages and ~1.2 kg immune cells in total Interesting paper: pnas.org/doi/full/10.10… *calculations based on "a standard reference human, historically characterized as a male between 20 and 30 y old, weighing 73 kg, and having a height of 176 cm"

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Excited to share our new study on the heterogeneity of interstitial macrophages based on their chemokine expression -conserved in humans and mice- a major role is to orchestrate leukocyte recruitment and establish TLS formation. Xin Li Arlind Mara nature.com/articles/s4159…

Greatly honored and fortunate to work with Claudia Jakubzick and the team on this study. It's been my PhD thesis project since before my first RIP. Excited to see that it finds a good home. This work could not be done without Claudia's support. Look forward to the future journey!

Worlds within worlds: The hidden functional diversity of macrophages Xin Li Arlind Mara Shawn Musial Fred Kolling nature.com/articles/s4159…

On the Summer Solstice with a 🍓 full moon, I got TENURE and will be promoted to Full Professor!! Yeah 🤗

Our new study investigates mouse alveolar mac heterogeneity & compares their divergence & evolutionary conservation with human counterparts. Naive mouse AMs are thought to be homogeneous. But, like human AMs, they exhibit vast heterogeneity. atsjournals.org/doi/10.1165/rc… Xin Li

Thank you so much! I’m honored to receive the Strohbehn Medal and grateful for the incredible training and support from the Jakubzick Lab and MCB community!🙏🎓