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Join our team! We are looking for a dynamic and motivated lab manager here at Yale. Please follow the link to find more information and apply! hhmi.wd1.myworkdayjobs.com/en-US/External…

Such an amazing work showing a lipid transport protein localizing to cluster of endocytic vesicles. Congrats Mike!!

We'd like to give a big shoutout to William Hancock-Cerutti, ASAP's November Network Spotlight! As an alum of De Camilli Lab at Yale University, his #research helped understand the involvement of protein-mediated lipid transfer between organelles. Learn more about Will: parkinsonsroadmap.org/network-spotli…

Membrane remodeling properties of the Parkinson’s disease protein LRRK2 biorxiv.org/content/10.110…

Now we name TMEM249 as CATSPERθ and reveal many of its secrets in the CatSper channel assembly, trafficking and sperm motility! Great collaboration with Riccardo Percudani 🐳 and Ikawa (not on Tweeter) labs. biorxiv.org/content/10.110…

Mutations in LRRK2 are likely causative of Parkinson's Disease but LRRK2's function remains elusive. Exciting new work from Xinbo Wang from De Camilli Lab show a remarkable membrane remodeling activity! pnas.org/doi/10.1073/pn…

A complex of the lipid transport ER proteins TMEM24 and C2CD2 with band 4.1 at cell-cell contacts biorxiv.org/content/10.110…

Lysosome damage triggers acute formation of ER to lysosomes membrane tethers mediated by the bridge-like lipid transport protein VPS13C biorxiv.org/cgi/content/sh… #biorxiv_cellbio

Lipid transfer from the ER by Vps13 proteins is a key part of the cellular response to lysosome damage - see new work from De Camilli Lab in collab with @Shawn__Ferguson: biorxiv.org/content/10.110…

Lysosome damage triggers acute formation of ER to lysosomes membrane tethers mediated by the bridge-like lipid transport protein VPS13C biorxiv.org/content/10.110…

Johnson et al. De Camilli Lab Yale Neuroscience show that the ER-anchored lipid transfer protein TMEM24/C2CD2L & its paralog C2CD2 mediate ER–plasma membrane junctions at cell–cell contacts by interacting w/ band 4.1 proteins & indirectly w/ cell adhesion proteins hubs.la/Q02LK29G0

A complex of the lipid transport ER proteins TMEM24 and C2CD2 with band 4.1 at cell-cell contacts. New study from Ben Johnson, Pietro De Camilli De Camilli Lab and colleagues Yale Neuroscience: hubs.la/Q02LK1Nt0 #Membrane #lipid #CellSignaling #Neuroscience #ER_literature

.Berrak Ugur et al De Camilli Lab Yale Cell Biology Yale Neuroscience characterize the bridge-like lipid transfer protein VPS13B & report its localization btwn #Golgi cisternae & its impact on Golgi complex reformation after BFA-induced dispersion. hubs.la/Q02Rm3lt0 Florian Schueder @MLeonzino

YSM teams led by Thomas Biederer, PhD, Pietro De Camilli, MD, and Clemens Scherzer, MD, will use three new #grants, awarded by Aligning Science Across Parkinson’s in partnership with michaeljfox.org, to advance understanding of, and future treatments for, #ParkinsonsDisease. brnw.ch/21wOSFB

A STING–CASM–GABARAP pathway activates LRRK2 at #lysosomes, say Amanda Bentley-DeSousa (@abentleydesousa ), Agnes Roczniak-Ferguson, and Shawn Ferguson (@Shawn__Ferguson) Yale School of Medicine: hubs.la/Q032HgqG0 #Disease #CellSignaling #Organelles #Parkinsons

In a recent study published in Nature Cell Biology, a Yale Neuroscience team says mutations in #genes responsible for regulating the lysosome – the "trash can" of the #cell – may result in the leakage of toxic substances in brain cells, leading to #Parkinson's disease onset.