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Super excited to share our work: inhibiting Ca2+ channels in Alzheimer’s disease model mice relaxes pericytes, improves cerebral blood flow and reduces immune cell stalling and hypoxia. nature.com/articles/s4159… 1/6

How can we teach high school students in any geography about the power and magic of CRISPR gene editing? Sarafan ChEM-H Institute Scholar Stanley Qi Lab and affiliate Michael C. Jewett Stanford Engineering developed this affordable kit! nature.com/articles/s4146…

With less than a month until we hit Asilomar State Beach for the #WRISG2024 meeting we are thrilled to announce this years recipient of the John C. Hutton Rising Star Award - the amazing Nicole Krentz 🙌👏🙌👏🙌👏🙌👏🙌👏🙌👏🙌👏🙌

Immune perturbations in human pancreas lymphatic tissues prior to and after type 1 diabetes onset. biorxiv.org/content/10.110…

We welcome investigators to submit their abstracts to present orally or at our poster session during the 17th Annual Scientific Meeting! Deadline is November 18th at 5PM: npod.org/abstracts

Join us this Thursday Oct 10 for Sam Stephens from University of Iowa The University of Iowa FOEDRC on metabolic control of insulin secretion.

Loss of atrial natriuretic peptide signaling causes insulin resistance, mitochondrial dysfunction, and low endurance capacity #obesity #diabetes Science Advances science.org/doi/10.1126/sc…

I am hosting Sam Stephens today for his islet metabolism talk. DM Islet Research Seminar Series for link 👇

Reduced beta cell PC1/3 and increased alpha cell PC1/3 in #islets from donors with type 1 diabetes may encourage the design of therapeutic targets via leveraging alpha cell adaptation in #diabetes Diabetologia link.springer.com/article/10.100… #T1D Bruce Verchere

Quantitative analysis of islet prohormone convertase 1/3 expression in human pancreas donors with #diabetes Diabetologia link.springer.com/article/10.100…

What an incredible group of Islet Biologists - making #WRISG2024 memories - Anna Gloyn Julie B. Sneddon @HuisingLab

Our paper is finally published! fun and awesome collaboration with Yi-Chun Chen, PhD and Bruce Verchere focused on understanding PC1/3 loss in beta cells and the concomitant increase in alpha cells during the development of type 1 diabetes. link.springer.com/article/10.100…

Beta cell prohormone convertase 1/3 (PC1/3) is reduced in T1D Paola S. Apaolaza Yi-Chun Chen, PhD Bruce Verchere Dr. Teresa Rodriguez-Calvo (DVM, PhD) nPOD Diabetes BC Children's Hospital Research Institute Helmholtz Munich | @HelmholtzMunich #DiabetesResearch #Islets tinyurl.com/4rkxty6v 🔓

Excited to share our new paper in Scientific Reports showing reduced GLP-1R levels and perturbed cell-specific transcriptional programs in islets from CFRD subjects. rdcu.be/dYli7 Thanks to all co-authors, including Sina Gharib and Rebecca Hull-Meichle for their contributions.

This is great! NIAID News have launched a collection of public domain illustrations (currently 550 individual icons) bioart.niaid.nih.gov

New: We investigated why lack of prohormone convertase 1/3 (PC1/3) in mice leads to sepsis hypersensitivity. We find that there is no role for PC1/3 in immune cells and that lack of PC1/3 in the HPA axis ➡️ less steroids is responsible for this phenotype. academic.oup.com/jes/article-ab…

APEX peroxidase is a versatile tool for proximity labeling and electron microscopy (EM) but its requirement for toxic H2O2 is a liability. We now report LaccID, a multicopper oxidase evolved from an ancestral fungal laccase that oxidizes aromatic substrates using non-toxic O2

There are 3 days left to submit an abstract to present at our annual meeting!

This week Nov 21 Dr. Teresa Mastracci discussing mRNA translation in beta cell growth and differentiation.

How to write a grant? 1. Write it for the reviewer, not you, the applicant. 2. Communicate in stories. 3. Make your story cohesive—leave no puzzling gaps. 4. Make your story resonate to keep the reviewer reading. 5. Accept chance and noise in peer-review. pnas.org/doi/epub/10.10…