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Excited to see the revised version of our paper now published at Cell Genomics led by Yevgeniy Serebrenik cell.com/cell-genomics/…

Our take on striking new findings from the Ryskeldi-Falcon lab on hybrid protein filaments in disease. I suspect this will be the tip of the iceberg, and there are additional implications for normal cell biology from their study. nature.com/articles/d4158…

Open season on FOXA1! Our paper with the Cravatt group is out today in Molecular Cell. Please check out the updated data, including a new discovery that FOXA1 ligands mirror the effects of a nearby prostate cancer mutation. authors.elsevier.com/a/1jxLO3vVUPRn… (1/2)

Excited to share our new paper where we explore why dCas9-KRAB protein levels drop so drastically after neuronal differentiation in WTC11 and KOL2.1J iPSC lines. biorxiv.org/content/10.110…

Thrilled that our work on the functional effects of EML4-ALK assemblies in cancer cells is now published in Nature Communications. Herculean effort through 2.5+ years of peer review by David Gonzalez-Martinez and Lee Roth. nature.com/articles/s4146…

Single cells can learn without a nervous system, but how? In our new preprint, Deepa Rajan and I describe a simple model for habituation in Stentor cells, based on mechanoreceptor internalization and recycling, and test it with quantitative experiments. biorxiv.org/content/10.110…

The Serebrenik Lab is hiring! Join us in unraveling proteostasis with pooled protein tagging and manipulation! Interested postdocs can learn more & meet other excellent labs at the Rutgers Postdoc Peek (Apr 3-4, 2025). Apply by 1/8/25: rutgers.ca1.qualtrics.com/jfe/form/SV_en…

NLS-binding deficient Kapβ2 reduces neurotoxicity via selective interaction with C9orf72-ALS/FTD dipeptide repeats: nature.com/articles/s4200…

Excited to announce our move to Stanford and the Arc Institute! We're hiring postdocs to explore the interplay between immune cells, metabolites and the microbiome in cancer, inflammation and metabolism. Apply here: postdocs.stanford.edu/prospective/op… #Postdoc #Stanford #ArcInstitute

Very excited to share our new paper out in nature today, led by my amazing postdoc, Qingfei Zheng (now at Purdue University) in collab w/ The Maze Lab (with Li & The Muir Lab) showing a beautiful mechanism of monoamine modification swapping in neurons 🤩 rdcu.be/d5CNc

The Kappel Lab is opening soon at UCLA and we’re hiring Staff Scientists to help lead our wet-lab projects & to assist with lab management! We have open positions for candidates with a PhD & for recent college grads. Learn more and apply: forms.gle/76inzTL6FoTcRP… Please RT!

I am extremely proud to see our work about Hepatitis B now published in Cell. From basic research to identifying the key step of infection & a potential first drug for curing this devastating disease. This has been an incredible journey.🧵 cell.com/cell/fulltext/…

🚨Paper alert 🚨 Our latest research is out in nature! We reveal a surprising new role for the proteasome in innate immunity: generating antimicrobial peptides that can directly disrupt bacterial membranes. 🦠⚡ Weizmann Institute Systems_Immunology_WIS 🔗 nature.com/articles/s4158… 🧵👇

Thrilled to see our work now published in Molecular Cell! It was an incredible privilege to do my postdoc with Ophir Shalem and work alongside the super talented Steph Sansbury and our amazing co-authors. Excited to keep building on this research in our new lab at Rutgers RWJMedSchool!

Excited to to see our collaboration with GB lab published today! This is part of our ongoing long term goal of achieving scalable non-disruptive and direct imaging and perturbation of the endogenous proteome science.org/doi/10.1126/sc…

Scouring the human Hsp70 network uncovers diverse chaperone safeguards buffering TDP-43 toxicity biorxiv.org/content/10.110…

Our lab at the Weizmann Institute was hit tonight by Iran We will rebuild and return 💪

In the nucleus, many intrinsically disordered proteins (IDPs) form condensates. What IDP sequence features drive this behavior? We developed CondenSeq, a high-throughput method to measure nuclear condensate formation & applied it to ~14000 IDPs to find out rdcu.be/eq975

So you want to change transgene expression: just change your promoter, right? Changing the promoter increases RNA and thus protein levels. What more could be happening? [1/n] Well, promoters don’t just set RNA levels; they uniquely transform how RNAs are transmitted into protein