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Why do Pseudomonas aeruginosa have not one, but two MlaA-like proteins? Turns out that one protein is part of a classic maintenance of lipid asymmetry pathway while the other joins forces with a periplasmic phospholipase!   pnas.org/doi/10.1073/pn…

A new paper from our lab is out today after peer review: science.org/doi/10.1126/sc…

A feedback control mechanism governs the synthesis of lipid-linked precursors of the bacterial cell wall biorxiv.org/cgi/content/sh… #biorxiv_micrbio

Here’s the latest from Luke Yaeger and friends! We’ve been studying this common but poorly understood phenomenon for a while. “A genetic screen identifies a role for oprF in Pseudomonas aeruginosa biofilm stimulation by subinhibitory #antibiotics” biorxiv.org/content/10.110… 1/4

Finally 🎉! From Luke Yaeger et al: Central metabolism is a key player in E. coli biofilm stimulation by sub-MIC antibiotics JPCôté Eric Brown McMaster IIDR 1/n journals.plos.org/plosgenetics/a… 1/8

New from PhD candidate Luke Yaeger and friends - a fascinating dive into the connections between #folate and #peptidoglycan pathways in #Pseudomonas that inspired Luke to design a dual-function inhibitor that targets both! McMaster IIDR McMaster Biochemistry & Biomedical Sciences 1/11 biorxiv.org/content/10.110…

Awesome new paper from Marvin Whiteley on disulfide Zn chelators, their role in intermicrobial competition, and defense mechanisms (based on oxidation back to disulfides).

pGpG-signaling regulates virulence and global transcriptomic targets in Erwinia amylovora biorxiv.org/cgi/content/sh… #biorxiv_micrbio

Synthesis of lipid-linked precursors of the bacterial cell wall is governed by a feedback control mechanism in Pseudomonas aeruginosa | Nature Microbiology nature.com/articles/s4156…

Redefining development in Streptomyces venezuelae: integrating exploration into the classical sporulating life cycle mBio by Evan Shepherdson and Marie Elliot journals.asm.org/doi/10.1128/mb…

Happy to share our latest by Luke Yaeger & Mike Ranieri - #Pseudomonas aeruginosa biofilm stimulation by sub-MIC #antibiotics! 1/9 nature.com/articles/s4152… rdcu.be/dCiT7

I’m stoked to share one of the last stories of my PDF McMaster IIDR. Found a potential way to prevent infection-associated urinary stones by blocking nickel uptake in K. pneumoniae. Thanks to all who helped make this paper happen @gerryiidr Prehna Lab nature.com/articles/s4146…

If you've induced phages, you may have wondered if you can do the 'opposite' - block entry into lysogeny. You can, using protein synthesis inhibitors! Better still, this yields a potent synergy, functionally turning a temperate phage into a virulent one. journals.asm.org/doi/10.1128/mb…

Inducible transposon mutagenesis for genome-scale forward genetics biorxiv.org/cgi/content/sh… #biorxiv_micrbio

Our paper on the sequence diversity of the ribosome-targeting apidaecin-like peptides found in the synthetic gene library is out: academic.oup.com/nar/article/do…

CRISPRi-Tn-Seq! Great collaboration with @tvanop nature.com/articles/s4156…

Read about macrolones, the antibiotics that target the ribosome and DNA gyrase: pubmed.ncbi.nlm.nih.gov/39039256/. A great collaboration with the Polikanov lab (UIC) and Liang lab (BIT).

It is hard to beat nature in the design of antibiotics. In this review, we analyze the sophisticated mechanisms of many antibiotic substances with an eye toward future antibacterial drug discovery. nature.com/articles/s4158…

Check out some great structural work on AmpG, a PG recycling transporter I think is very cool!