We are looking for postdoctoral fellows and welcome friends from all over the world to contact us. Our official website is yilab.org.cn

I’m super excited to start my new journey as Gene Regulation Observatory Fellow Broad Institute and a Junior Fellow of the Society of Fellows Harvard University. I will lead an independent group to study the principles and mechanisms of genome organization underlying development, disease, and evolution.

Absolute quantification of single-base m⁶A methylation in the mammalian transcriptome using GLORI - Peking University go.nature.com/3zmJj9p

Congratulations to our "GLORI" team!

We are pleased to introduce our new idea of RNA base editing, a safe RNA base editing tool. Excellent work by Dr. Jinghui Song Jinghui and Liting Dong! Click to view the full article ↓ authors.elsevier.com/a/1gFSa3vVUPK9…

Always double check your work. Huanan Herman Zhao discusses extensive off-target editing in the nuclear genome induced by a mitochondrial base editor. nature Chengqi Yi Peking University #JRNLclub jrnlclub.org/research-films…

Always double check your work. Huanan Herman Zhao discusses extensive off-target editing in the nuclear genome induced by a mitochondrial base editor. nature Chengqi Yi #JRNLclub jrnlclub.org/research-films…

Congratulations to Chuan He, 2023 Wolf Prize laureate in Chemistry! UChicago Chemistry The University of Chicago

🚨 New #NRMCBReview Alert! 🚨 "Regulation and functions of non-m6A mRNA modifications" by Hanxiao Sun, Kai Li, Cong Liu and Chengqi Yi This Review discusses the emerging functional mechanisms and roles of various non-m6A mRNA modifications. 🔗go.nature.com/3pLzvUU

The first approved CRISPR medicine in the world for sickle cell disease and beta thalassemia! A huge victory for biotechnology, patients, and humanity businesswire.com/news/home/2023…

We have witnessed this moment!!!

Thanks Julia. This is an awesome summary of current HYERs!

Honored that our RNA base editor "RESTART" has been selected as the best technology of Molecular Cell 2023. Huge thanks to my mentor Prof. Yi (Chengqi Yi). …bestof2023.elsevierdigitaledition.com/main/119/index…

#RESTART #RNAEditing We are delighted that RESTART has been recommended as one of the "Best of Cell Press" and published in Molecular Cell . This is a novel and elegant RNA editing tool developed by Dr. Jinghui et al. Link to our paper: sciencedirect.com/science/articl…

SIMPLE-seq Nature Biotechnology developed by Dr. Dongsheng Bai Dongsheng Bai et al. that simultaneously detects 5mC and 5hmC at the single-cell and single-molecule level! Jointly published by Prof. Chenxu Zhu Chenxu Zhu from Cornell University and us. nature.com/articles/s4158…

A cool technology developed by my colleague Chengqi Yi at Peking University to correct premature termination codon mutations doi.org/10.1038/s41587…

Near-cognate tRNAs increase the efficiency and precision of pseudouridine-mediated readthrough of premature termination codons - Peking University go.nature.com/3ToILdE

AlphaFold2 and RoseTTAFold are limited to predicting the 3D structure of proteins. A new all-atom method models complete biomolecular assemblies, including proteins, nucleic acids, small molecules, metals, and covalent modifications. #NBThighlight science.org/doi/10.1126/sc…