Excited to be at #AAI2023! Check out our posters: P443 - Sagar Gupta P444 - Yi Sun P1026 - Jo P1035 - Michael Young #immunology2023

Grateful to be part of this distinguished group of #WomenInSTEM 👩🏻‍🔬

Looking forward to presenting our posters today at 2:30 PM! #AAI2023 The American Association of Immunologists (AAI) P444 - Yi Sun P443 - Sagar Gupta P1026 - Jo P1035 - Michael C. Young

.Yi Sun attended the 37th #Gibbs Conference in Carbondale. It was a great opportunity to present our work on #MHC/#TAPBPR #xeno interaction and tell the story of using biophysical tools to solve immunological problems!

.Yi Sun attended the Cancer Grand Challenges #NexTGen conference and presented a poster on our latest work – structure-guided therapeutic expansion of a peptide-centric #CAR. Great opportunity to explore new research from different labs!

Deciding which patients can receive #CAR T therapy is an important clinical question. By uncovering the structural basis of #MHC antigen recognition by a #neuroblastoma-targeting CAR we double the patient cohort and limit off-target toxicity Science Immunology science.org/doi/10.1126/sc…

By solving the crystal structure of the 10LH-PHOX2B-HLA-A*24:02-β2m complex, we identify critical interactions b/w the CAR + pHLA & validate them w/ alanine scanning + SPR binding studies. The key residues are the peptide P6 arginine & framework residues along the HLA α1 helix.

Congratulations Possu Huang Lab! Such a versatile platform!

In Stanford Bioengineering’s Professor Possu Huang’s lab, Haotian Du is engineering novel proteins which could enhance our ability to detect more cancer types.Possu Huang Lab