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Happy to share our new spatial transcriptomics study for reconstructing 3D tissue organization at the single-cell resolution. It’s the work of exceptionally talented student YCF with Arpan Das 😷. biorxiv.org/content/10.110…

We call our new method scHolography. It learns inter-pixel information from spatial transcriptomic data to infer 3D tissue organization and cell-cell interactions at the single-cell level. Please use our package and share your feedback! github.com/YiLab-SC/scHol…

It’s a great collaboration with Rosemary Braun. Biology+single genomics+deep learning = back to future!

Grateful to a group of highly dedicated scientists in the lab. Something new and important will come out from today’s hard work.

Congratulations to Michael Sande, our first research assistant at Northwestern, on securing admission to the Cellular & Molecular Pathology graduate program at University of Wisconsin!

Super excited to share our newest study of mechanical properties of hair follicle stem cells and manipulate mechanical forces to activate hair growth by using a microRNA in collaboration with Dr. Srikala Raghavan Jie Yan Kathleen J Green pnas.org/doi/10.1073/pn…

There’s no better feeling to send off our first research assistant, Michael Sande, to embark on his new journey at graduate school! Wishing him all the best at UW Madison. Go conquer, Michael!

Happy to share two of our newest studies. In the study of MOF and H4K16ac, we found essential functions of MOF in controlling mitochondria and primary cilia in the skin. The regulation is prominently mediated at gene promoters. nature.com/articles/s4146…

In our analysis of single cell transcriptome and open chromatin during aging, Chi Zhang found the transcriptome of hair follicle stem cells is influenced by the hair cycle whereas their niche is less sensitive. frontiersin.org/articles/10.33…

The results, from both studies, suggest oxidative phosphorylation (mitochondria), cell adhesion and robust differentiation are key to hair growth and aging.

It’s the time of the year. Let’s first congratulate our two Harvard-bound students. Ayasa is our research assistant and she will join the graduate program at Harvard biology. Anisha is an IMSA student ,and will join Harvard college as undergraduate student this fall.

Very excited to share our newest tool: scHolography for reconstruction and quantitative analysis of spatial neighborhoods. Fantastic work by YCF and collaboration with Rosemary Braun. Visit github.com/YiLab-SC/scHol… for tutorials. genomebiology.biomedcentral.com/articles/10.11…

Congrats to YCF to successfully defend her beautiful thesis work of single cell genomics of the skin. Thanks Kathleen J Green @yogeshgoyallab and Rosemary Braun. Due to Driskill Graduate Program in Life Sci procedures, Cady will publicly present her work next Wednesday. Let celebration begins!

Congrats to our fantastic dermatology fellows, Ed and Steve, to receive prestigious Dermatology Foundation Career Development Award and Research Fellowship. Steve also won a Skin of Color Society research award.

Congrats to our exceptional graduate student, Chris Stephens, to receive a prestigious NIH F31 predoctoral fellowship to study metabolism in the skin!

Excited to share our new work in collaboration with Jie Yan and The Green Lab We 1) determined 20pN force through E-cad is sufficient to activate PIEZO1; 2) quantified Ca dynamics and identified their downstream targets in hair follicle stem cells. science.org/doi/10.1126/sc…

The surprising findings are 1) the force of 20pN through Ecad is sufficient to activate PIEOZ1; 2) AP1 factors control numerous ECM and actin genes in stem cells. How to leverage force to control hair growth is our next focus!

Congrats to YCF to graduate from the DGP in 4 years after joining our lab in 2021. Cady is our first ever graduate student at Northwestern, and she has heralded a new era of single cell spatial transcriptomics in the lab. We wish her the best and continued success at SF!