🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

Viral Architecture of SARS-CoV-2 with Post-Fusion Spike Revealed by Cryo-EM biorxiv.org/cgi/content/sh…

So society’s *real* key workers have just been revealed. Not the bankers. Not the traders. Not the elite hedge fund managers. It’s the nurses. The doctors. The delivery drivers. The carers. The porters. The teachers. The shelf stackers. The check out staff. #COVID19

A conference Covid can't cancel... CCP-EM Spring Symposium//Online is ready! 27 April-1 May Full details: ccpem.ac.uk/training/sprin… & registration: ukri.zoom.us/webinar/regist…

We’re recruiting! Interested in lipids and how they interact with immune pores? Come join our team with Nick Brooks findaphd.com/phds/project/c…

Congrats to Xinyu for such a great achievement!

🎁 Currys PS5 code giveaway 1x PS5 VIP code to redeem in-store by 27th June. Disc and digital bundles subject to availability. Ends today at 6pm. - Follow PS5 UK Stock - Like and retweet this tweet If you have a spare code, consider donating it to our community giveaways 🙏

Our scientists have discovered how special #proteins in the blood prevent our immune system from harming our own cells with overproduced molecules. ⤵️ ow.ly/rzJ350GtME5

Results from new detector for THERMO FISHER-SCI Tundra #CryoEM . Do I see some donuts? Join us on 7/13 at ter.li/vbj3dn to hear more about how we did it. Movie credit lingboyu

ICR is a fantastic place to work! And people in structural biology division are lovely.

Check out our work on uncovering structural heterogeneity from cryo-ET data! It was so fun working with and learning from Ellen Zhong, Abhay Kotecha, and other co-authors on this project!

Working with small protein targets? Use a scaffold. Has been tried multiple times with some success, but this one looks promising. "Cryo-EM structure determination of small therapeutic protein targets at 3 Å-resolution using a rigid imaging scaffold." pnas.org/doi/abs/10.107…

CryoEM tweeps, how do you typically calibrate pixel sizes using e.g. apof data? Compare to existing structure? Use Cs refinement from processing? LocScale with —refine_apix argument?

In case you want to know what we are up to. New review out written with Sjors Scheres and Benjamin Ryskeldi-Falcon. nature.com/articles/s4158….

BREAKING NEWS The 2023 #NobelPrize in Physiology or Medicine has been awarded to Katalin Karikó and Drew Weissman for their discoveries concerning nucleoside base modifications that enabled the development of effective mRNA vaccines against COVID-19.

Our Arctica has now a F4i + Selectris X filter and it is fast and good 🚀🔥 A few hours of data collection without particles polishing led to a 1.88 Å structure with cryoSPARC. Thank you Swiss National Science Foundation for funding support and TFS ppl for their work so far Microscopy & Spectroscopy.

Thrilled to present our manuscript out today in Cell. A tour-de-force on anaphylatoxin complement receptors - 9 (!!!) unique GPCR structures: C3aR/C5aR1, biased/partial/full agonist, Go/Gq, mouse/human. doi.org/10.1016/j.cell…

Hiring alert 🔔! 2 PostDoc Positions in our lab (4 years starting contract), core funded, top notch infrastructure (check Paolo Swuec ) and top colleagues ! Multidisciplinary projects combining EM with XL-MS and single molecule! Apply at careers.humantechnopole.it/o/postdoc-vann…

Excited to share our newest full collaboration with Bubeck Lab. We provide structural insights that help explain how mutations in gp130 that do not disrupt cytokine binding cause signaling defects and immunodeficiencies in humans. doi.org/10.1038/s41467…, Cell Signal and Immunology, University of Dundee

After a hard year, I’m glad to see this finally over the line. A real team effort from ⁦Yibo Jin ⁦Scott Gardner⁩ ⁦Tomas Voisin and others from ⁦Moraga Lab. As always, amazing data collection support ⁦eBIC Beamline⁩ #cryoem ⁦ nature.com/articles/s4146…

The structures of protein kinase A in complex with CFTR: mechanisms of phosphorylation and reversible activation | bioRxiv biorxiv.org/content/10.110…