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Genome modeling (left) by yqi:

Our paper on whole-genome modeling is online (doi.org/10.1016/j.bpj.…) and highlighted as New and Notable in Biophysical Journal (doi.org/10.1016/j.bpj.…)! Nicely done, Yifeng!

Check out this great effort from Xingqiang Xinqiang Ding in computing the "absolute" free energy which will enable calculation of free energy difference between states without extra sampling for intermediate states.

Great work from Wenjun @Wen_Jun_Xie in using the generative model for characterizing a "folding coordinate" for chromosome folding using single-cell imaging! #PLOSCompBio: Characterizing chromatin folding coordinate and landscape with deep learning dx.plos.org/10.1371/journa…

Our collaborative paper with Shixin Liu from Rockefeller University is out. Well done, Xingcheng! Single-molecule and in silico dissection of the interaction between Polycomb repressive complex 2 and chromatin pnas.org/content/early/…

Our paper on tetra-nucleosome stability is now published in Nat Comm (nature.com/articles/s4146…). We computed a six-dimensional free energy surface using a neural network approach and quantified the stability of fibril vs irregular configurations.

I am delighted to share our preprint on nucleoli formation (biorxiv.org/content/10.110…). We found that the chromatin network can slow down the kinetics of phase separation and stabilize a multiple-droplet state.

Our work on nucleoli formation is published in Nat Comm (nature.com/articles/s4146…)! See the MIT News release (news.mit.edu/2021/molecular…). Great work, Yifeng!

.yqi, a graduate student in Dr. Bin Zhang's (Bin Zhang) lab, discovered how #nucleoli droplets remain stable across an entire #CellCycle, instead of fusing together to minimize surface tension. 💧 Learn more: bit.ly/30XMCWu

Our collaborative work with Zhe J. Liu and Tjian + Darzacq Group is now published in Nat Genet. Huge thanks to Frank Xie lab and yqi for their years of effort! nature.com/articles/s4158…