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It shouldn't be hard to acknowledge the significant efforts of early sc cell-cell communication studies (CellPhoneDB) on establishing a comprehensive ligand-receptor knowledge base while also agree that most algorithmic follow-ups have been based on very shaky biological ground.

A true legend. Long live the Neutral Theory.

How can single-cell multiomics push the development of novel CAR-T therapies? Our new Cancer Discovery review explores current single-cell applications in the CAR-T field & discusses how this technology will empower clinicians with powerful decision-making tools for optimized treatments

A few months ago, I got an email: ”Congratulation - Best Paper Award in Theoretical Computer and Information Sciences: Bioinformatics”. Supposedly for our paper ”RNA velocity of single cells” (with Peter Kharchenko PeterK) 🧵

Our work on ILC3 meditating immune aging of the mouse intestine is now published.

Looking for insights from and datasets of single-cell profiling of treatment-perturbed human TME (tumor, blood, TDLN, etc.)? Check out our latest review titled "Single-cell dissection of tumor microenvironmental response and resistance to cancer therapy".