🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

The gene editing tool STITCHR contains an R2 retrotransposon fused to a CRISPR–Cas9 nickase to install diverse edits, including multi-kilobase insertions, in vitro. nature.com/articles/s4158… #NBTHighlight

Self-assembling protein nanoparticles for cytosolic delivery of nucleic acids and proteins go.nature.com/4mxazJw

High-resolution laminar recordings reveal structure-function relationships in monkey V1 biorxiv.org/content/10.110… #biorxiv_neursci

Wrote it this morning for a student and thought it may help others.

In the latest issue! Engineered nucleocytosolic vehicles for loading of programmable editors dlvr.it/TKshNX

A multi-kingdom genetic barcoding system for precise clone isolation go.nature.com/4ksLOMD

Our work is now online in the new Neuron issue Neuron, alongside other labs from the BRAIN Armamentarium Consortium! We have developed enhancer-AAVs to target diverse cortical interneuron subtypes: cell.com/neuron/fulltex…

Disturbed engram network caused by NPTXs downregulation underlies aging-related memory deficits biorxiv.org/content/10.110… #biorxiv_neursci

Technologies to modulate induced proximity at the cell surface advance the manipulation of diverse biological responses go.nature.com/4c9hu6M rdcu.be/em3WN

Wouldn't it be great if we could not only image large connectomic volumes, but also completely reconstruct them? And if a whole mouse brain project didn't cost billions? With the PATHFINDER preprint (biorxiv.org/content/10.110…), we preview a future where it doesn't have to.

Happy to share the latest preprint from the lab. Work examining the role of somatostatin neuropeptide transmission in the PFC in regulating associative learning underlying discrimination between salient and neutral outcomes. Led by Miguel Arenivar 🇺🇸🇲🇽🐭🧸🧪 biorxiv.org/content/10.110…

Brain network dynamics reflect psychiatric illness status and transdiagnostic symptom profiles across health and disease biorxiv.org/content/10.110… #biorxiv_neursci

Excited to share our work in Nature Communications on long-term stable and miniaturized wearable ultrasound transducer system for transcranial neuromodulation! Congratulations to our Texas BME PhD student Kevin Kevin Tang , postdoc Jinmo and the whole team! nature.com/articles/s4146…

In vivo deep-brain microscopy at submicrometer resolution with refractive index-matched prism interfaces biorxiv.org/content/10.110… #biorxiv_neursci

Hour-long voltage imaging in behaving mice! Capitalizing on the high photostability and brightness of mBaoJin, we developed eFRET GEVIs, named ElectraOFF, which extends reliable single spike detection at cellular resolution beyond one hour biorxiv.org/content/10.110…

Fos labels a distinct excitatory neuron ensemble for memory retrieval biorxiv.org/content/10.110… #biorxiv_neursci

Introducing Epi-PHR, the first non-disruptive, high-genomic-resolution, image-based epigenetic profiling method. Allelic Epi-PHR generates the first single-cell phased examination of histone mark deposition and 3D genome architecture at an imprinted locus by any technique. 1/8

In the latest issue! SLC7A11 is an unconventional H+ transporter in lysosomes dlvr.it/TLbwCs

CRISPR just scored its biggest win yet against Huntington's. The secret? A delivery system called RIDE that sneaks into neurons, makes its edit, then vanishes in 72 hours. Here's what happened 🧵👇

Top 5 advances in medicine this week (🧵) 1. Adults can produce new neurons, after all A decades-old problem is whether adults can produce new neurons. It’s been proven in mice – but never in humans This is the stunning discovery that the full pathway of new neurons - from the