A new probiotic-guided CAR-T platform uses engineered bacteria to infiltrate and produce synthetic antigen targets, enabling CAR-T cells to find, identify, and destroy tumor cells in situ. Learn more in this #SciencePerspective: scim.ag/52v

THIS.

Far too many cancers are detected late, when treatment may be less effective. A new National Cancer Institute-supported study estimates the # of lives that could be saved if more people receive currently recommended cancer screening. go.nih.gov/2Waw97y #CancerScreenWeek

Excited to share our work on ACS Central Science! We used acetlylysine to replace Lys73 of OXA-48 and showed NaCl altered the antibiotic effectiveness by promoting a newly discovered inactive acyl-enzyme intermediate.@YuanHe_NWU @the100footpole Yi Jin pubs.acs.org/doi/10.1021/ac…

Out Now! Our new preprint of mechanism of #PINK1 activation at TOM complex. Led by Wale OLAWALE RAIMI & Hina MRC PPU Fantastic collaboration with Ruben Fernandez Sebastian Mathea Aligning Science Across Parkinson’s Karim Labib Neil Ranson Tom Deegan. #OpenScience click here surl.li/oqvpt

A few years back I started a journey to learn more about biopharma and drug discovery. Here is a list of the books I have found helpful (loosely grouped by topic) with the outstanding books highlighted by (+++). Feel free to add your own recommendations, I'll keep adding mine.

What an away win for Cardiff City U14 basketball team today! Great move from Teilo 🔥 @BrgVibe

Edrych ymlaen at brynhawn o ymgysylltu ag ysgolion Grangetown a Youcef Mehellou fel rhan o wythnos Gyrfaoedd a Modelau Rôl! Looking forward to an afternoon of engagement with the schools of Grangetown and Youcef Mehellou as part of Careers and Role Models week! #STEM

The landscape of small-molecule prodrugs bit.ly/43I3X1U This new review analyses approved prodrugs to reveal trends in their development, highlighting design rationales, indications, mechanisms of API release, chemistry of promoieties and the market impact of prodrugs

“My time at the MRC PPU was truly formative for my scientific career." Gerta Hoxhaj Lab, MRC PPU Alumni & winner of the prestigious 2024 The Vilcek Foundation Prize for Creative Promise in Biomedical Science Full interview on our website: ppu.mrc.ac.uk/about-us/alumn…

📢 Two new preprints alert! LRRK2-a kinase associated with #Parkinson’s and #crohn's #IBD. But where is it expressed and active? Not in Paneth cells, important for Crohn’s, but IL-4 induced in B cells, and other immune cells- see tinyurl.com/mwz4py7u tinyurl.com/mpvfhw44

**MEETING ALERT** Biochemical Society Aligning Science Across Parkinson’s 20th Anniversary meeting on #PINK1 mutations in #Parkinsons. Fantastic lineup of speakers; industry and clinical talks and many early-career speaker slots. To register and learn more click: shorturl.at/LnXZM

📢In this year's GPhC registration exam, our graduates performed top in the UK with a pass rate at first attempt of 93%. We're very proud of their achievements! 🎉

New opportunity for a Lecturer (Assistant Professor) in Chemical Biology at the University of Bath! bath.ac.uk/jobs/Vacancy.a…

Post-doctoral fellow position for 3 years on the structural biology of signaling complexes downstream of LRRK2 kinase, in the lab of Amir Khan, Dublin, Ireland. This is a collaborative position with Dario Alessi at the MRC PPU, Dundee, Scotland ppu.mrc.ac.uk/careers/recrui…

Very sad news of the passing of Fraser Stoddart, a giant of chemistry for four decades. He pioneered (with J-P Sauvage) the chemistry of the mechanical bond (catenanes & rotaxanes) & recognised that their well defined motions could be useful for molecular machinery... 1/3

Great news - Accession receive MHRA approval for first in human clinical trial of TROCEPT-01 across six UK sites in a range of recalcitrant tumour types. Fantastic to see an agent initially developed Cardiff University in my Viral ImmunoTherapies & Advanced therapeutics Lab. make it to clinic. mailchi.mp/9425dbf8fce8/a…

We are deeply saddened to share that our friend and colleague Professor Amos B. Smith III has passed away. Amos joined Penn in 1973 and was a mainstay in our organic chemistry division. He recently celebrated 50 years of service to Penn Arts & Sciences Penn.

Happy to share that our paper looking into the role of OSR1 kinase in promoting breast cancer oncogenic potential is now out. Cardiff Pharmacy pubs.acs.org/doi/10.1021/ac…

Fully funded PhD studentship available in my lab in Cardiff University. - Most suitable for candidates with interest in medicinal chemistry and drug discovery. - Closing date: 21/03/2025. - Contact me for enquiries. Cardiff Pharmacy findaphd.com/phds/project/a…