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Data-driven modelling of neurodegenerative disease progression: thinking outside the black box — a Review by Alexandra L. Young, Neil P. Oxtoby, Sara Garbarino, Nick C. Fox, Frederik Barkhof, Jonathan M. Schott & Daniel C. Alexander go.nature.com/492x4yg

Happy to see our work published in Imaging Neuroscience! We compare different types of brain network for modelling pathology spread in AD, and show how we can combine the different networks to improve our models 🧠 Code here: github.com/ethompson93/mu… UCL POND UCL CMIC

Are you an early-career scientist interested in learning about the latest advances in medical image computing? The 10th UCL Medical Image Computing Summer School (MedICSS 2024) will take place from 1st – 5th July 2024 in person in Central London. ucl.ac.uk/medical-image-…

New pre-print alert! The aim of this study was to identify imaging subtypes of CBS based solely on a data-driven assessment of atrophy patterns, to test the hypothesis that modelling disease subtype and stage jointly would provide information on underlying pathology in CBS.. 1/7

‼️ Postdoc ad // Please RT/circulate ‼️ Are you interested in * Big euroimaging and multi-omic data? * Neurodegenerativ disease? The BioFINDER is looking for a talented postdoc to sink their teeth into some rare and exciting data! Apply here: lu.varbi.com/en/what:job/jo…

Extremely happy to see this one out at last!!!🎉🎊 Here, we showed that a single CSF draw 💉is sufficient to accurately stage participants along the #Alzheimer's continuum. This has been a long and tough journey, but totally worth it to finally share it with the whole community☺️

The first EU-MIND Congress takes place on 25-27 September in Caen, Normandy. The deadline for submitting your neuroimaging abstracts and travel awards is today. Be sure to submit! eu-mind.org/abstracts-subm…

Disease progression modelling reveals heterogeneity in trajectories of Lewy-type α-synuclein pathology Sophie Mastenbroek strikes again! Using SuStaIn modeling of neuropathological data (n=814) we show substantial heterogeneity in the temporal spread of Lewy body pathology, with

I am hiring a research technician to help process and analyze multimodal neuroimaging data. Please RT!! * Great opportunity to gain research experience pre-PhD * Access to exciting data * Opportunities for independent projects Apply here: lu.varbi.com/en/what:job/jo…

I'll be talking about multi-modal connectomes for modelling tau spread on Wednesday morning (4-2-FRS-D) and showcasing our group's network spreading model toolbox tomorrow at the AIC and in the poster session on Monday (Monday-475, AIC-340) 🧠🧠🧠 github.com/ucl-pond/netwo…

For more network-spreading goodness, check out Sonja Soskic's poster (Monday-910), where she uses the toolbox to model the impact of neurotransmitter receptors on amyloid and tau accumulation ✨ UCL POND UCL CMIC

Estarellas et al. report that an adapted Subtype and Stage Inference algorithm accommodates missing data in multimodal #Alzheimersdisease studies. Mar Estarellas MIG POND UCL Neil Oxtoby (Toybox Science) Jonathan Schott Daniel Alexander Alex Young edin.ac/3SjesUI

‼️PhD Position now available in my lab‼️ Do you like: * Neurodegenerative disease? * Neuroimaging and/or multi-omics? * AI and data-driven life science? Want to work with RikOssenkoppele Alexandra Young and Laura Wisse? Apply here: lu.varbi.com/what:job/jobID… Please rt/share 🙏

Andrew Zalesky and I will organize a symposium on "Unraveling brain heterogeneity across scales, systems, and diseases" at OHBM 2025! We have a great line-up of speakers (Alex Young Christos Davatzikos Ye Ella Tian, Maria Di Biase, and myself) who will discuss cutting-edge topics,

#AAIC2025 Monday TALK by Alex Young from UCL POND: 4:15pm, session 2-32-FRS-A. "Disease timeline modelling of amyloid and tau PET reveals dynamic timescales of amyloid and tau accumulation in Alzheimer's disease"

#AAIC2025 Monday POSTER by Lawrence Binding 🧠 from UCL POND: Monday-437. "Uncovering regional atrophy not explained by tau deposition using Additional Pathology Inference (AddiPath)" A new SuStaIn... :-)

#AAIC2025 Wednesday TALK by @chris_ucl from UCL POND: 2pm, session 4-23-DEV. "Longitudinal trajectories of advanced cortical diffusion-weighted imaging measures of tissue microstructure in pre-symptomatic autosomal dominant Alzheimer's disease"

#AAIC2025 Wednesday POSTER by Maitrei Kohli from UCL POND & MANIFOLD lab: Wednesday-410. "AutoML-Multiverse: Model Agnostic Framework for Optimizing Individual-level Alzheimer's Disease Classification"