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CLU alleviates Alzheimer’s disease-relevant processes by modulating astrocyte reactivity and microglia-dependent synaptic density: Neuron cell.com/neuron/fulltex…

Thrilled to share my first first-author paper is out in Neuron! We show that Alzheimer's disease protective CLU alleles upregulate CLU in response to neuropathology, dampening inflammatory signaling between microglia and astrocytes. Read here sciencedirect.com/science/articl…

New TYP lab paper out today in Neuron led by PhD student Alex Lish! We took a deep dive into the mechanisms underlying CLU in AD using innovative iPSC, mouse, and human data approaches. Be sure to give it a read! cell.com/neuron/abstrac…

Tracy gave a great talk at the 3rd Targeting Therapy of Alzheimer’s and Related Neurodegenerative Disease Conference in Chania, Crete! Huge thanks to Peter St. George-Hyslop, Li-Huei Tsai & Riqiang Yan for an incredible meeting. So many inspiring talks! #TargetAD25

TYP-ers attended the BIGG meeting at UMass on Monday, and had a great time presenting talks and posters! PhD student Gizem Terzioğlu & postdoc Kellie gave amazing short talks, Master's student Emma Karp & postdoc Sarah Heuer, PhD got great poster traffic!

A big day for the TYP lab! Master's student Emma Karp successfully defended her incredible thesis work today where she's been working with Gizem Terzioğlu on studying how SHIP1 regulates lysosomal function in microglia. She will be missed!

Excited to see our recent study featured on Alzforum! Thank you for highlighting our new study on how AD risk variants at the CLU locus lower astrocytic clusterin, disrupt neuroimmune crosstalk, and drive synapse loss. Read it here: alzforum.org/news/research-…

Well deserved!! We are super lucky to have an amazingly dedicated mentor. Congratulations Tracy!

With the support of Dr. Frank Ondrey, the RADC is pleased to present the Martha Ondrey Postdoctoral Prize to Sarah Heuer, PhD. Dr. Heuer presented on leveraging human stem cells to elucidate how polygenic risk affects cellular state transitions & communication networks in AD.

Shoutout to our lab at the ROSMAP meeting! Thanks David and the great team at Rush Alzheimer's Disease Center for a great meeting! 🎉 Sarah Heuer, PhD gave a great talk & won the Martha Ondrey Jr. Investigator Award 🏆 🧠 Gizem Terzioğlu crushed it with her presentation on SHIP1 & the inflammasome!

Huge congrats to our Master’s student Emma Karp for receiving the GBM Master Prize from the Society for Biochemistry and Molecular Biology! 🏆🧬 Emma earned it for her work in Biomedical Neurosciences at TUM! 🎓🧠 🔗 gbm-online.de/de/studium-kar…

🎓Congratulations to our incredible grads! 🎉 Dr. Lish and outstanding undergrads Seohyun Kim & Ellie Grogan are officially Harvard alumni! 🥂 We’re so proud of all you’ve accomplished—and can’t wait to see what you do next! 💫 Alex Lish

Thrilled to celebrate our incredible undergrad Ellie Grogan, who was awarded the Harvard Hoopes Prize for her exceptional senior thesis! 🏆📖 We’re so proud of her hard work and insight, and a great time taking her out to dinner to celebrate! 🎉🍽️

We are proud to celebrate Tracy as the recipient of the Harvard Medical School Clifford Barger Excellence in Mentoring Award! 🎉 Her guidance, encouragement, and dedication mean so much to all of us. Congratulations on this well-deserved honor!

Proud of our amazing postdoc Sarah Heuer, PhD 👏 who gave a fantastic talk today on her work leveraging stem cell models 🧫to examine the molecular and functional consequences of Alzheimer's disease genetic risk in microglia today as part of the BWH Neuroscience Seminar Series!

New TYP lab publication led by PhD student Alex Lish out today in Cell Reports! We present a reproducible neuron-astrocyte-microglia tri-culture model to study intercellular interactions in Alzheimer's disease. Read more here: cell.com/cell-reports/f…

Highlights from our lab at the Keystone Symposia Neurodegeneration meeting! Sarah Heuer, PhD delivered an excellent talk on ABCA7 loss and microglial dysfunction in Alzheimer’s! Alex Lish presented a great poster on CLU and intercellular communication in Alzheimer’s!

🧠 New study in Brain, led by graduate student Courtney Benoit, uncovers how the autism-linked gene POU3F2 supports brain development by promoting neural stem cell growth via Wnt signaling and key targets like ADNP and SOX13 academic.oup.com/brain/advance-…

Huge shoutout to our brilliant graduate student Gizem Terzioğlu for delivering a great HMS Neurobiology Pizza Talk! 🍕🧠 She highlighted exciting insights into how SHIP1 shapes microglial function at the intersection of intracellular trafficking and immune response.

Huge congrats to Zack Murphy, selected as a 2025 Fujifilm Fellow at Harvard Medical School !! 🎉 The Fujifilm Fellowship Program fully funds PhD students doing groundbreaking work in the life sciences! Look out for big things ahead from Zack!