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How do we detect touch? A new paper in Science Advances from Slav Bagriantsev & Elena Gracheva's teams at #Yale reveals the 3D structure of mechanosensory corpuscles, and sheds light on the mechanism of touch detection. #physiology #neuroscience medicine.yale.edu/neuroscience/n…

Mechanisms of PIEZO Channel Inactivation mdpi.com/2479994 #mdpiijms via IJMS MDPI

It’s time to announce that I am joining UCLA (Physiology Department) David Geffen School of Medicine at UCLA and will officially start my lab in November 2023.

Pentameric TRPV3: an artifact or a clue to channel function? Many structures of tetrameric TRP channel assemblies have been published. We discuss recent discovery of pentameric assembly of vanilloid TRP channel TRPV3 (doi: 10.1038/s41586-023-06470-1). sciencedirect.com/science/articl…

Molecular insights into the force-from-lipids gating of mechanosensiti... sciencedirect.com/science/articl…

Welcome back to #TraineeTuesday 🥳Today’s spotlight is on Yury Nikolaev, a postdoc in the Sensory Phys lab (a collab between PIs Elena Gracheva and Slav Bagriantsev), who just published a paper on touch detection. Let's dive into his research journey! [1/5]

Functional coupling between Piezo1 and TRPM4 influences the electrical activity of HL‐1 atrial myocytes - Guo - The Journal of Physiology - Wiley Online Library physoc.onlinelibrary.wiley.com/doi/10.1113/JP…

Cold shuts down the CNS? In ground squirrels the hypothalamic-pituitary axis neurons are active even at 10°C, as we show by the first ever fiber photometry in a mammalian hibernator. A new study from the Gracheva lab by Maddy Junkins and @fengni99 cell.com/current-biolog…

Check out our latest review on the accessory cells of touch receptors across species. #touch #glia #accessorycells #review #Merkelcells #pacinian #celegans #drosophila #duck frontiersin.org/articles/10.33…

Excited to share our latest collaboration with the @corrylab and Zhang Lab, this time on OSCA/TMEM63 channels out today in nature Victor Chang Cardiac Research Institute nature.com/articles/s4158…

jobrxiv.org/job/yale-unive…

A pervasive view is that TRP channels represent primary sensors of mechanical forces. Along with @PooleLab1 and Boris Martinac we reviewed the evidence supporting this in Trends in Biochemical Sciences cell.com/trends/biochem…

Great review on mechanosensivity of TRP channels. Conclusion: if any TRP channels are primary mechanotransducers, most robust evidence for NOMPC and TRPV4, they are activated under specific mechanical conditions and may require auxiliary components. cell.com/trends/biochem…

I feel hungry after just a few hours, but hibernating squirrels don't even after several months. This remarkable feat is possible due to reversible central hypothyroidism. A new study from the Gracheva lab by Sarah Mohr and Rafael Dai Prá rdcu.be/dNmeC

We report the 3D architecture and mechanism of touch detection by the Pacinian corpuscle. Contrary to the textbook knowledge, the outer core is dispensable for frequency detection. A new study by Luke Ziolkowski and Yury Nikolaev biorxiv.org/content/10.110…

Our story on the structure and mechanism of Pacinian corpuscle by Luke Ziolkowski and Yury Nikolaev is on the cover of Science Adv. science.org/doi/10.1126/sc…

New evidence shows that lamellar Schwann cells are a key element of somatosensory processing. Learn more in this week’s issue of Science Advances: scim.ag/43DyU8X