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What an absolute pleasure to be collaborating with such an incredibly talented team!! SPRINTER out today in Nature Genetics 🧬

#CRUKFunded scientists published a paper in Nature Genetics unveiling the first computational algorithm capable of identifying which cell populations within a tumour drive aggressive growth. SPRINTER is Simone Zaccaria's first output as part of their Career Development Fellowship.

Delighted to introduce our new spatial transcriptomics tool, SpottedPy, recently published Genome Biology, allowing the identification of tumour hotspots at different scales and the exploration of distances and overlap with tumour microenvironment niches: genomebiology.biomedcentral.com/articles/10.11…

We are so grateful to Qian_Du for this outstanding Nature Genetics News&Views piece highlighting our recent SPRINTER work and framing it so beautifully within the literature. A truly valuable resource! 🙏 Read it here👉 doi.org/10.1038/s41588… 🧵Dive into SPRINTER's work 👇

🎉 So hugely honoured and happy to be selected for the EMBO Young Investigator Programme 2024 EMBO YIP! Such an exciting opportunity for our group Computational Cancer Genomics (CCG) Research Group and so grateful for the support of UCL Cancer Institute UCL News UCL CRUKCOLcentre The Francis Crick Institute & our funders Science and Innovation at Cancer Research UK Cancer Research UK

Congratulations! Simone is on of our Career Development Fellows and now part of the EMBO Young Investigator Programme that supports young group leaders in Europe and beyond through funding, training and mentorship.

Huge congratulations to our faculty member Simone Zaccaria, who has been selected as an EMBO Young Investigator. This highly competitive programme supports a prestigious cohort of young group leaders through funding, training and mentorship. Find out more: embo.org/press-releases…

Are metastatic #cancers more like their normal origin or target tissues? Our work in Science Advances systematically compares the #transcriptomics of primary and metastatic #tumors to healthy tissues in a #PanCancer, genome-wide manner! #metastasis 🧵1/10 shorturl.at/Uc4xx

#TumorEvolution reconstruction is heavily influenced by algorithmic & experimental choices—this In the Spotlight commentary by Rija Zaidi & Simone Zaccaria highlights a recent Nature Biotechnology paper by Boutros Lab, Peter Van Loo, Kyle Ellrott, Maxime Tarabichi, et al. bit.ly/3VAMRQs

How much do algorithmic and experimental choices drive the accuracy of reconstructing tumour evolution? In this Cancer Research commentary, Simone Zaccaria and I discuss a recent Nature Biotechnology benchmarking paper exploring this question:

🚨Very proud of this commentary led by Rija Zaidi reasoning on the method and experimental design impact on cancer evolution understanding, motivated by the outstanding work of Boutros Lab, Peter Van Loo, Kyle Ellrott et al Orig. work 👉 doi.org/10.1038/s41587… Our Commentary 👇

🙏 I am so grateful to UCL Cancer Institute and all my colleagues at the institute for their constant and incredible support 🙏 Thanks to EMBO and EMBO YIP for this great opportunity; excited for the journey ahead!

Be a part of ISMB/ECCB 2025: Shape the future of computational biology. Attend in-person in Liverpool or virtually for live sessions, Q&A, and exclusive networking. Elevate your research at the forefront of bioinformatics!

🚨Thrilled to share our latest work: “Tumor-Infiltrating Clonal Hematopoiesis” NEJM - we investigated how age-related blood mutations impact cancer when they infiltrate tumors, with Elsa Bernard Maria Zagorulya, Elli Papaemmanuil, PhD Charles Swanton + more nejm.org/doi/full/10.10…

There’s much more in the paper: 👉 Single-cell genomic data from patients with TI-CH Adam Mead 👉 TI-CH in metastases, including autopsy samples from the PEACE study Cancer Research UK 👉 Functional experiments with the help of many labs, including Dominique Bonnet's The Francis Crick Institute

Excited to see our NEJM paper out on tumor-infiltrating CH, tumor evolution, and patient outcomes. A privilege to work w/ friends Oriol Pich and Maria Zagorulya with invaluable support from Elli Papaemmanuil, PhD and Charles Swanton Memorial Sloan Kettering Cancer Center The Francis Crick Institute Gustave Roussy 👇👇

Now the incredible Mariam Jamal-Hanjani presenting data from the TRACERx Peace cohorts defining the metastatic cascade in Nsclc ⁦Science and Innovation at Cancer Research UK⁩ ⁦UCL Cancer Institute⁩ ⁦The Crick⁩

1 in 2 people will get cancer in their lifetime. Our Computational Cancer Genomics (CCG) Research Group 'll still run Cancer Research UK Muddy Race also this May to highlight the importance of funding cancer research Science and Innovation at Cancer Research UK and improving patient outcomes Please support us if you can! #RaceforLife 👉 fundraise.cancerresearchuk.org/team/computati…

Huge congratulations to Lucrezia Patruno from Computational Cancer Genomics (CCG) Research Group for being awarded one of the best abstract awards at AI in Oncology in Paris, we are so proud! Join ISMB to hear her full story on the next advances in call CNAs from single cell seq!

We're a month out from #ISMBECCB2025!  You can now access the abridged agenda, downloadable schedules, poster listings, and SciFinder search tool links directly from the homepage: iscb.org/ismbeccb2025/h… Click the link you need, or use the Programme &  Agenda menu for more