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Pathologists! What’s your differential for this dense lymphoplasmacytic infiltrate causing multiple lesions on torso?#hemepath #dermpath

🌖Different Faces of Plasma Cells 🌔 #2 Pleomorphic Cytology: 🌝Large size 🌝Multi-nucleated or multi-lobated 🌝Abundant pale-blue cytoplasm

🌔Different Faces of Plasma Cells🌔 #3 Lymphoid-Appearing Plasma Cells 🌝Closely resemble lymphoma, particularly MCL 🌝Commonly express CD20 and cyclin D1 🌝Often t(11;14)(q13;q32) 🌝Consider CD138 during initial workup frequently

🌔 Different Faces of Plasma Cells 🌖 #4 Anaplastic Cytology 🌝Marked nuclear pleomorphism 🌝Abundant pale-blue, vacuolated cytoplasm 🌝Resemble carcinoma, sarcoma, melanoma, etc ...particular extra-medullary cases 🌝Consider CD138 for undifferentiated neoplasm

🌔Different Faces of Plasma Cells🌖 #5 🔥Flame Cells🔥 🌝Pseudopodic cytoplasmic projections 🌝Pink staining of peripheral cytoplasm 🌝Usually associated with IgA myeloma 🌝Also seen in other myelomas and reactive plasma cells

Sunset after a 6-mile run

First sunrise of 2021 over the peaceful Atlantic Ocean...

"Gastrointestinal Tract Lymphomas: A Review of the Most Commonly Encountered Lymphomas" Alvarez-Lesmes et al. #EarlyOnline #gipath #hemepath buff.ly/3argtrY

Beautiful sunset after a tempo run. Madison, CT.

#ICYMI. Team effort by @YalePathology pathologists, Smilow Cancer Hospital oncologists leads to fast diagnosis & treatment. Thanks to Mina L Xu Amer Zeidan MBBS,MHS ‏عامر زيدان, Nicole DeJesus, William Laskin MD, Francine Foss MD, Kristina Fanucci MD & others. Yale School of Medicine Yale Cancer Center bit.ly/3vlTY1c

Just had a case recently…

Last day at Yale! Really enjoyed my time here during the past four years. Truly a great place with tons of opportunities and surrounded by inspiring people. Will miss all my colleagues, staff members, residents, and fellows so much!!

Thrilled to share our work where we characterized HHV8-negative effusion-based large B-cell lymphomas. I am grateful to be able to work with such brilliant colleagues and mentors, specifically Zenggang Pan, MD, PhD, FCAP and Mina L Xu. nature.com/articles/s4137…

We will remember Dr. Duffy as an incredibly gifted teacher... Even after his retirement, he made regular appearances at our weekly hematology conference to continue sharing his knowledge. Sending our deepest condolences to his family 🤍 medicine.yale.edu/news-article/i…

Spent two days last week in the Rocky Mountains to enjoy the Colorado Fall Colors. Truly amazing views. vimeo.com/872081488/3251… (images and videos taken by iPhone)

New Mod Path paper on erythroblastic sarcoma: authors.elsevier.com/a/1kpW-3B8d91x… Planning 2 related projects. Collecting cases: 1）adult AEL or ES associated with myeloid neoplasm (MPN, MDS, MPN/MDS, AML, etc); 2) pediatric AEL or ES Please Email if interested: [email protected]