
The Zhang Lab
@zhanglab_ut
The Zhang Lab @UTAustin - unraveling the principles of transcriptional regulation and its impact on brain tumors and neurological diseases
ID: 1535402367977496576
https://sites.cns.utexas.edu/zhanglab/home 10-06-2022 23:29:26
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biorxiv.org/content/10.110… One never forgets their first love, mine being the Pol II CTD. Thankful to contribute to this new preprint from The Zhang Lab implicating phospho-CTD codensates in the recruitment of splicing factors to elongating pol II + proper splicing in human cells.


Despite rumors, no postdocs were harmed in the first ever Molecular Biosciences postdoc symposium.











The Zhang Lab This work builds on findings by numerous groups that phosphorylation can regulate CTD (and by extension, Pol II) condensation. Here we show CTD interaction proteins that recognize phosphorylation marks modulate CTD condensate formation and topology 3/n

It was really fun to work with The Zhang Lab again who was a valued mentor and champion for me early in my career. I appreciate the opportunity to contribute to this work.


We are excited to share our most recent publication, led by Lucas Miller - wherein we use structural & biochemical techniques to uncover the site of 8-oxo-rG recognition by polynucleotide phosphorylase & its impacts in-vitro & in-vivo! #whatstartshere 🤘🏾pnas.org/doi/10.1073/pn…

Getting the 1st structural & biochemical view of how this enzyme interacts with its oxidized RNA has been exciting work for our lab, led by my student Lucas Miller in collaboration with Resendiz Lab, The Zhang Lab , CSSB UT & Phanourios Tamamis (Texas A&M). #whatstartshere 🤘🏾