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#LaborDayHighlight #4 - finally, following Alan Brown & Susan Shao’s duet (pubmed.ncbi.nlm.nih.gov/30015201/), our lab’s talented Samantha Webster, @mirabellamay1, Barrett Powell composed this thoughtful review arxiv.org/abs/2308.16019 of the intertwined history of ribosomes and #cryoEM.

Together with Eddie Lee, our Md/PhD students Ben Creekmore and Katie Kixmoeller developed a new method using cryo-PlasmaFIB milling to enable cryo-ET imaging of fresh human brain tissue from autopsy! biorxiv.org/content/10.110…

I learned so much while doing my PhD with Tarun at the Kapoor Lab and this learning experience was life-changing. Also the Tri-institute Chemical Biology Program TPCB really cared and helped the students, especially during challenging times.

Another new avenue of investigation from the Vale lab.

Our paper is out! We resolved the sheath structure from M. Hungatei cells using cryoET. ⁦⁦Thanks to all the coauthors The Zhou Lab⁩ and Gunsalus lab.⁦#TeamTomo nature.com/articles/s4146…

Great to see the r-TuRC in action!

Please join Elizabeth Villa and me next week American Society for Cell Biology #cellbio2023 for a workshop on “The Future of Structural Biology”. We have 4 amazing early stage investigators (BhabhaEkiertLab Zhen Chen @Navarro_PaulaP Eric Mulhall). Takes place on Monday at 10:30 AM in Room 204 B.

Beautiful images!

The annual American Society for Cell Biology #cellbio2023 meeting calls for a lab reunion! It was great to see many former lab members at the meeting, where we caught up for a fun dinner! Scott Forth Kuo-Chiang Hsia Rudolf Pisa Shih-Chieh (Jeff) Ti Zhen Chen

Interested in studying cellular and development biology by advancing cryo-electron tomography? We have openings for postdocs to resolve in situ protein structures at the atomic scale: bbe.caltech.edu/jobs/postdocto…

Got to mark this post for building processing machines in the future.

More development at the frontier of tomo processing!

Very excited to see our work on PRC1 and chromatin condensation online Molecular Cell cell.com/molecular-cell… I am grateful to have worked with and learned from Sharon and Theresa Oei during this project! Many thanks to Radhika and Bob for their guidance and support throughout!

Caltech is hiring a senior scientist to manage our new FIB-SEM! I really enjoyed this exceptional environment for tackling diverse and exciting biological problems, surrounded by brilliant minds. Please spread the news! phf.tbe.taleo.net/phf03/ats/care…

Amazing studies of the mechanochemical cycle of dyneins!

Well deserved! Great job Julian Braxton

Happy to share my last grad school paper, out in final form at NatureStructMolBiol. Chaperone and cryo-EM aficionados check it out! nature.com/articles/s4159…

rdcu.be/dY5rl The latest research article from Ti Lab. We employed cryo-EM structural analysis, single-particle fluorescence microscopy, and recombinant tubulin to reveal how tubulin acetyltransferases modify the K40 residue inside the microtubule lumen. (1/N)