🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

Our lab's latest paper describing a mutually inhibitory interaction between DPP9 and KEAP1 is now online jbc.org/article/S0021-…

Honored to have contributed to this review with Jay Schneekloth exploring the untapped potential of targeting protein-RNA interactions. Small molecules recognizing these pockets could open exciting therapeutic doors—think risdiplam and RocA, but beyond. (link in the thread)🧬 #RNA

Excited to share that TRACeR stories are out🙌

Here is our large-scale protein design story with Bruno Correia and Novo Nordisk! Using geometric deep learning, we evaluated the entire human surfaceome, identified 4,500 sites, and targeted them with a library of 0.5M seeds, equal to performing 3B docking! biorxiv.org/content/10.110…

Check out our work in ACS Central Science. We have developed a virtual noncanonical amino acid (ncAA) screener that allows evaluation of the genetic encodability of designed ncAAs prior to chemical synthesis. pubs.acs.org/doi/10.1021/ac…

The #FeMS+ 2025 Q2 Empowerment Award applications are open! Thanks to BrukerMassSpec for sponsoring. Apply here: airtable.com/appyGufCIumjAo… #TeamMassSpec #WomenEmpowerment

Today in nature we share our back-to-back stories with Ning Zheng revealing chemical-genetic convergence between a molecular glue & E3 ligase cancer mutations. 1/6

Really enjoyed this proximity-based therapeutics keystone conference! Appreciate the organizers Fleur @FleurMFerguson and Phil for the opportunity and for putting together this wonderful event!

If you are unsure about pursuing PhD at this stage, I am also hiring 1–2 JRFs with a background in organic chemistry. We have the funding and will train you in dye/click chemistry for applications in biology. Follow the website for details DyeCraftLab.com

Highly recommend! A great lab to join! 🎉

Absolutely honored to be selected 2025 CAS Future Leaders! Congrats to all the cohort and I look forward to join you in upcoming events! 🥳

🚨 Beyond thrilled to share that my PhD work is now available as a BioRxiv pre-print! 🥳 A huge thank you to my amazing colleagues, mentors, and collaborators at Scripps Research and AbbVie who supported and contributed to this project!

A small but meaningful milestone - our lab's first NIH grant NOA! Grateful for the support and excited to get to work! We're hiring! Candidates with experience in biochemistry, assay development, and structural biology are encouraged to apply!

Check out MuSIC 2.0, combining Human Protein Atlas images and HMSBioPlex interactions to make a multi-scale model of the cell. I enjoyed working on this with Trey Ideker, Emma Lundberg + their labs & collaborators. Special congrats to lead authors Leah Schaffer & Clara (Mengzhou) Hu!

Excited to share our latest study in JBC! We reveal how SIRT6 adapts to diverse histone acylations through structural and enzymatic plasticity, supported by a new cryo-EM structure of SIRT6 bound to H3K27-modified nucleosomes. jbc.org/article/S0021-…

I'm excited to share my lab's first preprint! It describes Affinity Map, a highly general method providing proteomic profiles of binding affinity for small molecules, peptides, and antibodies in cell lysate, organ extracts, and live cell surfaces. biorxiv.org/content/10.110…

🧵[1/10] A busy week for K-Ras! We report three stories on covalent, mutant-selective targeting of oncogenic K-Ras mutations ACS Publications. Covalent chemistry has been key in drugging this once “undruggable” GTPase. Sotorasib and adagrasib are the only approved therapeutics.