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Insights: James Walsh @WashUDOVS discusses study from Cao et al. (hubs.la/Q02SYpQw0) which demonstrates that, in #Alzheimers disease (AD), the influx of toxic Aβ from the brain to the retina underlies AD-induced retinal degeneration. hubs.la/Q02SY0Xg0 #Neuroscience

Happy New Year! I wish you all a healthy and successful 2025! In this #JEMLegacy tweet, I would like to bring your attention to two back-to-back papers published in 2000 by John E. Sims that cloned and characterized #TLSP and TLSPR. rupress.org/jem/article/19… rupress.org/jem/article/19…

Welcome to the future of #HumanImmunity research! Rockefeller U. Press and the International Alliance for Primary Immunodeficiency Societies (#IAPIDS) are launching the Journal of Human Immunity (JHI)! Stay tuned for groundbreaking, #OpenAccess research! 👉 hubs.la/Q032QmF50

“The impact of the collective executive orders and directives appears devastating.” scim.ag/4h5ngYC

In this #JEM_Spotlight tweet, we revisit the study by Marion Pepper & colleagues on how #allergen exposure alters the function of #influenza-specific lung CD4+ #TRM cells and impacts disease outcome following heterosubtypic influenza challenge doi.org/10.1084/jem.20…

1/ Spots are still open for the 2025 Henry Kunkel Society Meeting on Genes & Immunity! Join us in Belgrade from April 10-12, 2025. henrykunkelsociety.org/meetings/ #HKS2025 #Immunology 🧬🔬

A big shout-out to our Associate Editorial Board members!

In this month’s #JEMLegacy tweet, let’s go back to 3 papers published in 1990s by Drs. Bendelac, Lantz, Dellabona, Balk and colleagues on the identification of the invariant T cell receptors in #iNKT cells. rupress.org/jem/article/18… rupress.org/jem/article/18… rupress.org/jem/article/17…

In this #JEM_Spotlight, we highlight the study by John Harty & colleagues University of Iowa Pathology on the #regeneration of #CD8+ #lung #TRM cells after targeted #radiation exposure doi.org/10.1084/jem.20…

At today’s #JEMjc, we discussed three interesting studies about #Treg differentiation as well as function during #inflammation, #homeostasis and #regeneration. Nature Immunology Immunity Science Immunology nature.com/articles/s4159… cell.com/immunity/fullt… science.org/doi/10.1126/sc…

Tomorrow is #RareDiseaseDay. An exciting discovery today for COPA syndrome, a rare heritable autoimmune disease. Finding a protective allele that has the potential to lead to a cure rupress.org/jem/article-ab… Journal of Experimental Medicine This work was supported by the National Institutes of Health

Today is the #RareDiseaseDay2025. Journal of Experimental Medicine is committed to publishing studies that identify inborn errors of immunity, elucidate underlying mechanisms and propose potential treatments for rare diseases. Here are excellent examples. doi.org/10.1084/jem.20… doi.org/10.1084/jem.20…

RBM10 loss promotes #metastases by aberrant splicing of cytoskeletal and extracellular matrix mRNAs, say Gnana Krishnamoorthy (Gnana Krishnamoorthy), James Fagin and colleagues Memorial Sloan Kettering Cancer Center: hubs.la/Q037-z0-0 Vera Tiedje #SolidTumors #HumanDiseaseGenetics

Splicing factor RBM10 loss fuels #ThyroidCancer #metastasis. Kevin Coughlin and Ledong Wan Ledong Wan Stony Brook University discuss study by Gnana Krishnamoorthy and colleagues (hubs.la/Q037-xzn0) in Insights: hubs.la/Q037-QFH0

.Benjamin Broomfield, Groom et al. show that early type I interferon blockade alters CXCR3 chemokine regulation and cell location to promote an antigen-dependent CD8+ T cell transition of precursor of exhausted T cells to stem cell–like memory CD8+ T cells hubs.la/Q03b6ykm0

Pestal, Slayden, and The Barton Lab demonstrate that group 2 KLF family transcription factors are critical for specifying the identity of distinct tissue-resident #macrophages. hubs.la/Q03bvVl60

🎥 New video summary of a study from Du, Faz-Lopez, GUERY Jean-Charles, Barrat Hospital for Special Surgery (HSS) et al. (hubs.la/Q03by0Xx0) describing that TLR7 and TLR8 escape X-chromosome inactivation in plasmacytoid DCs of patients with systemic sclerosis. hubs.la/Q03by8vw0

Attending Keystone Symposia #KSTumorMetab25 in Vancouver? Get in touch with our Deputy Editor Cindy (Xin) Sun @Cindy_JExpMed who will be in attendance, and bring all your publication-related questions! Check out our Tumor #Metabolism collection 👉 hubs.la/Q03bK10l0

🎥 New video summary of a study from Vidyanath Chaudhary, Franck Barrat and colleagues Hospital for Special Surgery (HSS) (rupress.org/jem/article/22…) showing that mechanosensing regulates pDC activation in the skin through NRF2 activation. youtu.be/9Namb9CJnrM HSS Education Institute

This classic Journal of Experimental Medicine study (1955) demonstrated that lymph node cells can transfer transplantation immunity to foreign tumor transplants. A milestone in immunology! #JEMLegacy doi.org/10.1084/jem.10…