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News story about the paper led by Shirin Nouraein in our lab. Ultrasound can enhance delivery of AAV to throughout the brain, without neuronal or weight loss. Widespread delivery improved both the spatial distribution and efficiency. nature.com/articles/s4143… bioengineering.rice.edu/news/rice-doct…

🏆 Jerzy Szablowski (Jerzy Szablowski) is one of two Rice Bioengineerings selected as recipients of the NIH Director’s New Innovator Award (NIA). This award will, "support early-career investigators with ambitious, unconventional project proposals." 🏆 loom.ly/8fmrSTo

One of our postdocs Zhimin Huang is on the job market. It's an incredible feeling to see a new research program unfolding. He will be at the Biomedical Engineering Society meet the faculty candidate, poster #22-A and will work on monitoring protein behavior in intact cells t.ly/fFGtn

Many brain therapies are permanent. One can't undo surgical resection for epilepsy, or remove gene therapy from the brain. What if we could do a test drive? RAID is a new concept for non-genetic, temporary, localized pharmacological control of the brain. biorxiv.org/content/10.110…

Serum markers are very useful, but they can't track many processes in the body. What if we could make synthetic serum markers to track any process? What if we could measure gene delivery or neuronal activity with a blood test? see our paper Nature Biotechnology nature.com/articles/s4158…

Can AAVs be evolved for better brain delivery after targeted ultrasound insonation? We report new AAVs optimized for focused ultrasound BBB opening. Congratulations to all involved! Richard Hongyi Li Manwal Harb John Heath @JakeSTrippett Mikhail Shapiro (same on bsky) 🇺🇦 nature.com/articles/s4146…

Huge congratulations, Dr. Lee!

Heartfelt thanks to my family, mentors, colleagues, mentees, and friends for your great support. Special thanks to my mentor, Dr. Jerzy Szablowski at Rice University, for his exceptional guidance and inspiration. Your help has been invaluable on this journey. 2/2

How could we check if a gene therapy reached the desired brain region? Here, we noninvasively measure gene delivery and endogenous gene expression in specific brain sites with ultrasound-released synthetic serum markers. science.org/doi/10.1126/sc…

Announcing the 2024 SPAI postdoc seminar season BCMHouston. Happy to share that 2 of our inaugural 2023 SPAI speakers are now #newPI. SPAI's vision is to promote the next generation of future faculty who would also be good mentors! Apply by Sept 15th. form.jotform.com/241756255206153

Thank you so much for your kind words and encouragement, Jerzy Szablowski. I am truly grateful for your generous support and guidance throughout my postdoc journey.

Jerzy is the best mentor I have ever had. There is no doubt that you will enjoy the exciting research and his inclusive, vibrant lab.

Congratulations to Zhimin Huang on his $100k grant award from PhRMA Foundation to advance noninvasive, site-specific brain therapeutics, helping enhance therapy duration and efficacy while minimizing side effects. neurosurgery.pitt.edu/news/huang-awa… @upmc Pitt Health Sciences

Jerzy is the best mentor I have ever had. There is no doubt that you will enjoy the exciting research and his inclusive, vibrant lab.

Delighted our recent Huntington's disease article on mitochondrial toxicity of mutant huntingtin in JNeurosci was chosen to be highlighted by the journal. HDSA NINDS

Researchers and pediatric neurosurgeons at University of Pittsburgh School of Medicine and UPMC Children's Hospital of Pittsburgh have developed a new way to profile brain cancers in children, paving the way for improved diagnostics and treatments. science.org/doi/10.1126/sc… Gary Kohanbash Itay Raphael UPMC Science Magazine

Thank you to PhRMA Foundation for the opportunity to share more about our ongoing work supported by the Faculty Starter Grant. I’m grateful for the support and excited to advance noninvasive therapeutic strategies to improve brain health.

Big congratulations to Drs. González-Martínez, Niranjan, and the Pitt Center for Image-Guided Neurosurgery team!