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Our research and recent publication on evolutionary catalysis have been featured by UF News. Advancing enzymology by exploring the language of naturally evolved enzyme sequences. news.ufl.edu/2025/03/ai-to-…

We're excited to partner with the UK Government on OpenBind, an effort to create the largest open dataset of drug-protein interactions in history. More data → smarter AI models → better medicines gov.uk/government/new…

Chai Discovery (Joshua Meier Chai Discovery) just released Chai-2, a model for "zero-shot antibody design in a 24-well plate." The most existing result? Chai-2 successfully generated binders for 50% of the 52 targets they assayed (100x better than SOTA)! Some thoughts below:

One of the best parts of my role is having the privilege of being surrounded by passionate and brilliant scientists working on extremely difficult problems. The Chai Discovery team falls into that category unequivocally. I was pretty blown away by this data as well as the

Congratulations to Chai Discovery on this incredible milestone. We are proud to have partnered with the Chai team on some of the extensive experimental validation in the linked paper.

It's been a privilege work alongside the most uniquely talented group of individuals I've ever encountered on this breakthrough result Kevin Wu, Nathanael Rollins, Jacques Boitreaud, danny, Jack Dent , Joshua Meier, Zhuoran Qiao / 乔卓然 and others. You all made this possible!

this is so good it's a bit hard to believe.

It takes true inventiveness to break ground. This is pioneering work! And it makes me so happy to see Josh’s life’s work coming to life. Congratulations Joshua Meier, Jack Dent, Matt McPartlon, Kevin Wu, Nathanael Rollins, Jacques Boitreaud, danny, Zhuoran Qiao / 乔卓然, Paul Wollenhaupt & Alex!

This startup just dropped an AI model that will save many many lives. Chai-2 takes stubborn proteins and gives you a verified binder in 2wks, instead of 6-18mos. Its 16% hit rate is 100x better than previous methods! Medicine development is about to get way cheaper and faster.

Some use cases are cooler than others, and it's safe to say zero-shot antibody design is one of them. Congrats on launching Chai-2!🧬

THIS is what gets me excited about AI! Using generative techniques to solves previously computationally intractable problems is the real superintelligence. When this is more mature it'll give us unprecedented control over our biology. So cool.

Some scientists see the increasingly impressive results from protein binding models and argue "solving" this problem actually has marginal return on an end-to-end drug campaign in practice. Generally, they claim (1) traditional immunization / hybridoma assays are already quite

Listen to today's No Priors to hear why the Chai Discovery team is bullish on biotech. Thank you to sarah guo // conviction for hosting Jack Dent and Joshua Meier.

Chai-2 is now up on BioRxiv: biorxiv.org/content/10.110…

OrbitAll: A Unified Quantum Mechanical Representation Deep Learning Framework for All Molecular Systems Accurately modeling chemical systems across diverse charges, spin states, and environments remains a central challenge in molecular machine learning. No existing machine

Thrilled to be awarded the 2024 Tianqiao & Chrissy Chen Institute and Science Magazine Prize for AI Accelerated Research! This is a huge recognition for our past work on structure prediction foundation models, and the path ahead to pursue further. Looking forward to presenting more this October!

Checkout my essay at Science Magazine as part of the Chen & Science AI prize👇

HLE has recently become the benchmark to beat for frontier agents. We FutureHouse took a closer look at the chem and bio questions and found about 30% of them are likely invalid based on our analysis and third-party PhD evaluations. 1/7