Happy to share our latest RSC Chemical Biology on state of the art genomic methods to attain genome-wide mapping of G4-structures. Here you can find a step by step guide to select the best method for you 👇👇 pubs.rsc.org/en/content/art…

It was a great pleasure to be invited to give a talk at the Cambridge Chem&Bio Seminar. I shared my work on the mechanisms of inflammation and cell death triggered by bacterial toxins. Thanks to Dr. Zutao Yu for the invitation. Looking forward to more friends to join the group.

⭐ The Northern Lights over Cambridge! 📸 Dan Sayle for St John's College, Cambridge; Institute of Astronomy, Cambridge; @j_a_clarkson; Matheus Depieri. #NorthernLights #AuroraBorealis #Cambridge

Very comprehensive summary of RNA structure mapping, well done

Congratulations, Yuquan (Hamish) Tong. We ID RNAs bound by small molecules in cells versus ones cleaved by recruiting ribonuclease effector proteins. Amir also developed a pipeline to use the binding data to predict 3D rna small molecule pockets in human rnas, a hard. problem

Fabulous work using RNA nanostructure to design cellular condensates in situ

Happy (to know there is AUG) RNA day #RNA

Great to finally kick off the 8th RSC Nucleic Acids Cambridge Nucleic Acids Symposium #CamNA24. Looking forward to the great talks aligned over the next few days in the beautiful Queens College.

Chapter 2 of branched RNA: chemically modified branched cap for multi-capped mRNA and capped circular RNA (QRNA)--the cellular translation machinery is surprisingly tolerant of unnatural structures! Beyond enhanced performance, the mechanism is intriguing: rdcu.be/dUQKX

UPNAT Director Haiyan Zhou is keynote speaker at the upcoming Cambridge Chem&Bio Seminar on Nucleic Acid Research. Dr Haiyan Zhou UK Platform for Nucleic Acid Therapies- UPNAT Space is available on 14 Dec "whether you're a student, researcher, or simply curious about the field", book here: eventbrite.co.uk/e/12th-cambrid…

Really cool design: sending ASO to nucleus via conjugating JQ1.

Thanks to Yiliang Ding and Cambridge CSSA, I had the pleasure of attending this Cambridge Chem&Bio Forum. Great to meet new friends and explore AI applications in these fields. 🤝 Zutao Yu Dr Haiyan Zhou

🚀 New Paper Alert! 🚀 𝐑𝟐𝐃𝐓: a comprehensive platform for visualising RNA secondary structure Check it out in Nucleic Acids Res: academic.oup.com/nar/article/53… Here’s why you should give it a try 🧵👇

🚨 Preprint alert 🚨 We have developed an entirely new mechanism of action for ASO gene knockdown -> lysosomal trafficking 🧬! Works with non-DNA ASOs (unlike RNase H mech) and higher activity than corresponding gapmers! Led by Disha Kashyap UCL Chemistry Oxford Chemistry

A new #KwokLab paper has been released in Nucleic Acids Research: "A novel L-RNA aptamer to regulate the pUG fold RNA-induced gene expression in vivo." Congrats to the authors👏 doi.org/10.1093/nar/gk… CityU Hong Kong CityU Department of Chemistry College of Science, CityU @NAR_Open

What a night at RNA Club! 🔬✨ Packed room, groundbreaking science, and a networking session buzzing with ideas, laughter, and 🍕! Huge thanks to Kevin Weeks Weeks Lab @ UNC & Alessandro Bonetti Alessandro Bonetti for their fantastic talks. Can’t wait for more RNA discoveries ahead! 🚀

Exciting talk starts now by Matt Disney on the druggable transcriptome research Cambridge Chemistry

Great opportunities in Kwok lab, Hongkong

Caroline Dean Jonathan D G Jones ❤️

Scientists in Feng Zhang's lab have re-engineered a compact RNA-guided enzyme they found in bacteria into an efficient, programmable editor of human DNA. Nature Biotechnology Feng Zhang Broad Institute MIT Brain and Cognitive Sciences MIT Science mcgovern.mit.edu/2025/05/08/rat…