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Excited to share our latest paper led by Rachel Glenn. We generated a genetically diverse mouse pluripotent stem cell panel from the Diversity Outbred stock and outline experimental approaches for "population-scale" in vitro directed differentiation. biorxiv.org/content/10.110…

Our newest preprint identifies a role for p53 in balancing nutrient supply and demand by enabling phospholipid headgroup recycling 1/

Our DNA Typewriter protocol (written by Hanna Liao, Jay Shendure, and myself) is out! Thank you Nature Protocols for writing/editing this with us and having it as this week’s #FeaturedProtocol :-)

Our latest, from the brilliant Will Chen and Junhong Choi, out in nature , is ENGRAM, a multiplex method for symbolic recording of signaling and cis regulatory activity to DNA. Final version (not in preprint) includes integration w/ DNA Typewriter. rdcu.be/dN62L

Thrilled to introduce IRISeq, a scalable, cost-effective and imaging-free spatial genomic technique for mapping mammalian brain aging, developed by incredible Abdul AbdulAbdul and Weirong from our lab at Rockefeller University! biorxiv.org/content/10.110…

Today out in bioRxiv we present SCOPE. An optics-free, self-registering array of DNA encoded beads for spatial genomics. This was work led by the intrepid duo of Hanna Liao and Sanjay Kottapalli, with Jay Shendure's lab. biorxiv.org/content/10.110…

Excited to share our human RA-gastruloid model in Nature Cell Biology! Early retinoic acid supplementation, followed by later Matrigel addition, robustly induces human embryonic morphologies and diverse cell lineages, including somitic, renal, cardiac, and neural cell types in

Now accepting applications for our 2025 Cancer Biology & Cancer Engineering programs. Aspiring scientists & engineers will solve fundamental problems in biology & conduct research & develop technology that will help understand, diagnose, & treat cancer. bit.ly/3WUiuo1

Excited to share "Defining heritability, plasticity, and transition dynamics of cellular phenotypes in somatic evolution", from an amazing collaboration with Dan Landau Andrew R. D’Avino Tamara Prieto Toshiro Hara Mario Suva! A tweetorial, or Xplanation ... nature.com/articles/s4158…

Incredibly proud to share that I recently joined UCSF Bioengineering & Therapeutic Sciences UC San Francisco as an Assistant Professor! This means that the Calderon Lab is now open! Or, more accurately, in the process of opening as I am still unboxing equipment and unraveling giant posters (a last @JSHendure lab gift) 🥳

Beyond stoked to share our latest, entitled “Diversified, miniaturized and ancestral parts for mammalian genome engineering and molecular recording” ! biorxiv.org/content/10.110…

New synthetic biology / gene regulation lab opening in Zurich! We’re studying how to control cell state transitions – for example, making diseased cells healthy or creating new cellular functions – using systematic perturbations, single-cell genomics and machine learning. 🧵1/4

Amazing thread by Nature Reviews Genetics on our review paper! Thoroughly enjoyed being a part of this group :-) (+Will Chen, missed in the original post)

Finally out in Science Magazine! Utilizing the cost-effective EasySci to profile 21 million single-cell transcriptomes across five life stages and diverse sexes/genotypes, we reveal aging as distinct, development-like transitions, with dramatic cell population changes in specific