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Come join us at ISTA!!

We are hiring!! 📢 A Predoc position is available in the lab to bridge toward Ph.D. fellowships by Oct. 2024. All at the intersection of mechanistics of self-renewal, stem cells and cancer. Links to apply below

By making small genetic deletions that remove the loop anchor on one end, we show that it breaks the loops and impacts the expression of the other gene 190kb, 240kb and even 2.5Mb away. sciencedirect.com/science/articl… 2/4

Comparison of four transcription elongation factors reveals conserved regulatory mechanisms. New review by Ying Chen sciencedirect.com/science/articl…

COOLAIR and PRC2 function in parallel to silence FLC during vernalization - out now! 🌱❄️Great effort by all the authors (on twt Mathias L. Nielsen Eduardo Mateo / @emateobonmati.bsky.social Philip Wolff Shaoli Zhou)

Thrilled to announce the Gallini lab (gallinilab.com) will open the door this October EPFL Life Sciences. Excited to start this new chapter and eager to contribute to the stem cell and cancer biology fields with exciting new discoveries.

Excited to share our work showing how the Integrator complex terminates RNA polymerase II (Pol II) transcription i.e. removal of Pol II from the DNA template Published in nature nature.com/articles/s4158… Many thanks to my mentor Patrick Cramer Patrick Cramer for unwavering support

Very exciting! The future is bright but the scientific community needs access to the model to run large scale efforts.

Join us in this adventure in beautiful Aarhus! PhD and postdoc positions available! If you're passionate about DNA repair and structural biology, we have several exciting projects for you. Please contact me for more details, and please share with your colleagues!

I am delighted to share our latest paper on the Integrator complex assembly and association with transcription factors. Great work by Michal Razew, Angelique Fraudeau, Moritz Pfleiderer and Romain Linares EMBL EMBL Grenoble authors.elsevier.com/sd/article/S10…

I am thrilled beyond words to share with you all that our work, previously posted as bioRxiv, is now out in Molecular Cell Caroline Dean John Innes Centre Miguel Montez @Bobby_Mapes Xiaofeng Fang Lori Passmore @MRC_LMB Universidad Politécnica de Madrid CBGP cell.com/molecular-cell…

New preprint! 🧬🖥️ With the Johannes Walter, we created a predictome of nucleosome acidic patch binders using AlphaFold. Our approach identified both known and novel acidic patch interactors, opening new avenues for chromatin research. Check it out: biorxiv.org/content/10.110… (1/3)

Lucas Farnung Johannes Walter Did you know about this: github.com/KosinskiLab/Al… ?

“cBAF generates subnucleosomes that expand OCT4 binding and function beyond DNA motifs at enhancers.” Amazing story by GERARD Matthieu Marina Nocente. Congrats to all the authors. nature.com/articles/s4159…

Check out our latest review on Pioneer Transcription Factors (TFs) by Manuel Carminati, Luca Vecchia, and Lisa Stoos in Current Opinion in Structural Biology Current Opinion/Research in Structural Biology! Read it here: doi.org/10.1016/j.sbi.…

Our latest work on FANCD2-FANCI (D2-I), a complex that helps resolve DNA crosslinks and replication stress, is out! nature.com/articles/s4158… We show D2-I acts as a sliding clamp on DNA, stalling at single-stranded gaps to identify and protect damage sites. Lori Passmore David Rueda