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Prioritize biologically relevant ions for data-independent acquisition (BRI-DIA) in LC–MS/MS-based lipidomics analysis #Metabolomics link.springer.com/article/10.100…

Stable isotope dilution mass spectrometry quantification of hydrogen sulfide and thiols in biological matrices sciencedirect.com/science/articl…

Upcoming podcasts: Louise Burke, Benjamin Levine, Jerome Dempsey, Claude Bouchard, Laurie Goodyear, Juleen R. Zierath, Mark Hargreaves, Scott Trappe, Sandra Hunter, Jorgen Wojtaszweski, Hakan Westerblad, @JohnAHawley, Abigail Mackey , Jorgen Jansen, Eddie Coyle, Michael Kjaer.👍

Weekend plans acquired. 🤩link.springer.com/book/10.1007/9…

#Analogue #search drastically increases the annotation rate of metabolomics profiles. We here propose MS2Query: a machine learning based tool that builds on the advancements of our recently introduced machine learning based mass spectral embeddings #Spec2Vec and #MS2DeepScore.

Glucose clamps are a critical tool to gauge glycemic control. This Comment in Nature Metabolism is a great discussion of the uses of glucose clamps, and what they can (and can't) tell you. OA: rdcu.be/cRS4f nature.com/articles/s4225…

PhD Thesis defense💥 Alisa Nelson🌟 Bioinformatics and Computational Biology Program Wednesday Aug 3, 1 pm CDT Mayo 3-100 Title: Development and deployment of untargeted metabolomics pipelines to reveal molecular signatures of wellness Zoom ID 98162537702 See pic for passcode

Exercise timing influences multi-tissue metabolome and skeletal muscle proteome profiles in type 2 diabetic patients – A randomized crossover trial sciencedirect.com/science/articl…

The Lac-Phe discussion continues. A nice Preview discussing needed experiments to better understand physiological action.

Which training modes maximize health outcomes of exercise, HIIT or MICT? Answer: Yes. Reminds me of a certain recent conversation Curtis "Tug" Hughey frontiersin.org/articles/10.33…

Please check out the latest review from the Division of Molecular Medicine UMN DOM Research We (@puchatek22ch Peter Crawford) hope it is a useful resource for those interested in mitochondrial oxidative metabolism in NAFLD. sciencedirect.com/science/articl…

Maybe wondered about this a time or two 😂🫠 Peter Crawford @puchatek22ch #wtFAHFA

Loss of hepatic phosphoenolpyruvate carboxykinase 1 dysregulates metabolic responses to acute #exercise but enhances adaptations to exercise training in mice (Ferrol Rome, Curtis "Tug" Hughey et al. UMNNews) - new in AJP-Endocrinology and Metabolism ow.ly/msnH50MaUeP #gluconeogenesis #metabolism

New pod online with John Thyfault (TeeFo). How exercise impacts liver metabolism and protects against fatty liver even: -during hyper-caloric conditions -without body weight loss + Important sex differences Really interesting and important stuff! John is all over the literature!

Full agreement with many comments - never start something new Friday afternoon. I'll add: 1. It's probably an adduct (or noise) - that assumption can save a lot of heartbreak; 2. Get comfortable with troubleshooting as quickly as possible - it's part of the process.

Novel link Palmitate and Metastasis! Our study about the importance of this fatty acid in the metastatic niche is out in Nature Cancer !! We find that the secretome of breast primary tumors and high fat diet prime the lung for metastasis formation... (1/4) nature.com/articles/s4301…

Happy to share our manuscript, ‘Gender-based heterogeneity of FAHFAs in trained runners’ (biorxiv.org/content/10.110…). This work was led by the outstanding Alisa Nelson, PhD Species of the lipid class, fatty acid esters of hydroxy fatty acids (FAHFAs) are endogenous anti-diabetic 1/x

New article! Read Predicting labor onset relative to the estimated date of delivery using smart ring physiological data in npj Digital Med dlvr.it/SttKDf