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A perfect mix of structure-guided biochemistry and in vivo experiments to determine how the DISARM immune system recognizes phage DNA!

This is a first for me, a contaminant that turned my solid medium to liquid 😬🧫

Check out PhD student Amelia Schmidt's latest paper in collaboration with Karen Maxwell out now mBio: A Filamentous Bacteriophage Protein Inhibits Type IV Pili to Prevent Superinfection of Pseudomonas aeruginosa doi.org/10.1128/mbio.0…

Preprint by Cristian Aparicio-Maldonado ( TU Delft, Netherlands) and colleagues: Class I DISARM provides anti #phage and anti-conjugation activity by unmethylated DNA recognition. buff.ly/3rpcFzl

Rafa Pinilla-Redondo That’s what we proposed for DISARM - methyltransferase and nulease modules are clearly important yet DISARM still works if they’re not present. We speculated that other host methyltransferase and PLD nucleases can compensate, making those modules redundant

New bioRxiv feature: in-line figures for everyone! You can now print (or save as PDF) all articles with in-line figures, regardless of how the authors origiunally formatted them 1/n

#NoALaGuerra

.#Phagetherapy protocol approved: Phage Australia - Connect. Discover. Cure, a network of #phage researchers & clinicians, are excited 2 announce the approval of the STAMP phage therapy protocol, which regulates the process of phage therapy rather than a phage product specifically. buff.ly/3K7t17r

Very pleased to share our ✨New Paper✨ about an epigenetic conflict between a restriction–modification system and a methylation-dependent nuclease. Want to know how that pans out? Continue reading here 🧵👇🏻 or head over to Nucleic Acids Res for the full story: academic.oup.com/nar/advance-ar…

In eukaryotes, Argonautes (eAgos) are well known for their role in RNA-guided RNA interference. Prokaryotes encode Agos (pAgos) but lack other RNAi components. Instead, certain 'long' pAgos use DNA guides to target and cleave invading DNA such as plasmids and viruses. 2/11

This project was initiated by the magnificent Balwina Koopal who carried out most of the work with AnaP. Also many thanks to all other co-authors: Sumanth Mutte Cristian Aparicio-Maldonado Stan Brouns, Simon Lindhoud and Jacques Vervoort. Thanks NWO Domain Science (Inactive) and European Research Council (ERC) for funding! 11/11

Excited to share the final version of our DISARM story! How can bacterial confer incredibly broad antiphage immunity and yet avoid immunity? We think the answer may be due in part to DNA structural context and other mechanisms for cryptic specificity. nature.com/articles/s4146…

Congratualtions to my co-authors Cristian Aparicio-Maldonado Franklin Nobrega Stan Brouns David Taylor. This was the first project I took on in the David Taylor lab, and I'm really proud of the combination of cryo-EM, biochemistry and in vivo work we used to understand this fascinating system

Great work by my postdoc Jack Bravo NaturalSciences @ UT and Cristian Aparicio-Maldonado and Franklin Nobrega out in ⁦⁦⁦Nature Communications!⁩ First exciting collaboration with Stan Brouns. Structure of a complex that can broadly DISARM phage by grabbing and reading ssDNA tails! nature.com/articles/s4146…

Programazo el viernes en Toledo!!! Gracias Bioquímica en Movimiento Toledo por organizar esta jornada tan interesante!!

Filamentous #phages have a low burden on bacteria and compensate by providing services that aid in the formation of better #biofilms , delivering toxins and other factors that increase #virulence, or modifying their behavior to pro…lnkd.in/dRybs5Nm lnkd.in/d7EN4jW7

Finishing a PhD requires a lot more graphic design ability than advertised, folks...

Superb Postdoc position possibility with RikkeMeyer at iNANO - Interdisciplinary Nanoscience Center on investigation of the properties of secondary DNA structures in the extracellular matrix of bacterial biofilms international.au.dk/about/profile/…

This is a macrophage REPAIRING A BROKEN BLOOD VESSEL #MedTwitter #biology

Tomorrow 27th January, I will defend my PhD at TUDelft at 12 pm(GMT+1). My PhD research, entitled “DISARMing viral invaders of bacteria”, has been supervised by Stan Brouns and Franklin Nobrega Feel free to join the public defense lifestream: collegerama.tudelft.nl/mediasite/play… #phd #defense