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Science Twitter is fun, useful, and really nice—no, really by Dylan T. Burnette Dylan Burnette ascb.org/careers/compas…

Neat preprint from Brett Collins, Blessy Paul, Hanaa Hariri & others using crystallography & Alphafold to dissect architecture of SNX-RGS proteins. Surprisingly, two domains appear to fold together forming a new lipid binding/transfer module. biorxiv.org/content/10.110…

Why do my cells look blurry?

A highlight from Blessy Paul in Nature Metabolism on work from the Wolfrum lab. Interesting study that dissects PEX2 as a sensor of cellular ROS to fine-tune ATG-mediated lipolysis. nature.com/articles/s4225… You can read the original Ding et al study here: doi.org/10.1038/s42255…

Stay thirsty for discovery, cell bio folks

Congrats to Brett Collins & Blessy Paul! Paper suggests novel lipid binding module in SNX-RGS proteins via PXA-PXC domain interactions at interorganelle contacts. Great example of Alphafold solving riddles we've struggled to experimentally resolve. doi.org/10.3389/fcell.…

Attending ASBMB and interested in interorganelle crosstalk? Attend the organelle signaling session Sunday Apr 3 9:30-11:30 Rm126A. Hear about work from Blessy Paul, Brett Collins, Henne_Lab and others about the SNX-RGS proteins and their roles in interorganelle crosstalk

Super proud of grad student Natalie Speer Natalie Ortiz Speer 🇨🇷🇪🇨 who will give a talk at American Society for Cell Biology Symposium "Metabolism from Cells to Organisms" this Dec! #ProudPI Interested in how proteins 'label' specific lipid droplets & dedicate them to specific functions? See Natalie's work!

Many thanks to Deborah Wormser and the UTSW Media Relations Newsroom for highlighting our collaborative study on the phase transition properties of cholesterol. utsouthwestern.edu/ctplus/stories…

At ASCB #cellbio2022 & interested in lipid droplets? Check out some LD talks! ASCB is a great venue for trainees to speak! see Natalie Ortiz Speer 🇨🇷🇪🇨's talk on LD functional diversity see Rupali Ugrankar's talk on LD-cytoskeletal crosstalk see Mike's talk on liquid-crystalline LDs

New preprint! Led by Natalie Ortiz Speer 🇨🇷🇪🇨, here we characterize yeast protein Bsc2, showing it localizes to a sub-population of lipid droplets (LDs). Our data support a model where Bsc2 acts as a 'triglyceride sensor' on a LD subset to regulate lipolysis. biorxiv.org/content/10.110…

Meme your science: Triglyceride (TAG) rich lipid droplets are substrates for hungry TAG lipases. Are there ways cells protect some LDs from lipolysis? See our preprint to learn about Bsc2, which decorates a subset of TAG-rich LDs and inhibits breakdown. biorxiv.org/content/10.110…

Did you know you can monitor the biophysical phases of #lipid_droplets (LDs) using polarized light microscopy? Learn about this and other interesting aspects of LD biology in our recent mini-review/perspective in Current Opinion in Cell Biology, here: doi.org/10.1016/j.ceb.…

Extremely proud of grad student Natalie Ortiz Speer 🇨🇷🇪🇨! See her paper, now out in Journal of Cell Biology, where she characterizes a regulator of lipolysis that decorates TG-rich LDs. rupress.org/jcb/article/22…

Tld1 is a regulator of triglyceride lipolysis that demarcates a lipid droplet subpopulation, say Natalie Ortiz Speer Natalie Ortiz Speer 🇨🇷🇪🇨, Mike Henne Henne_Lab and colleagues @UTSWNews: bit.ly/3QuXeDn #LipidDroplets #lipids

Lipid droplets exhibit many functions including energy storage organelles & metabolic buffers. Did you know they also likely serve as optical light filters in chicken cone cells? Learn about this & more in this interesting paper now out in Developmental Cell. cell.com/developmental-…

Happy holidays from the Henne_Lab, having painting fun at our end-of-year day out.

I’m happy to see that our preprint of my postdoc work in the Henne_Lab is online! Thank you Mike for the shoutout!

Excited about our preprint led by the amazing Blessy Paul w/ collabs from Jeff McDonald (UTSW) and Steve Farber (Johns Hopkins)! Here we characterize the paraoxonase-like enzyme APMAP, showing it helps maintain lipid & lipoprotein homeostasis @ the ER. biorxiv.org/content/10.110…

Please re-tweet! We're searching for a Drosophila lab technician! Interested in Drosophila as a model to study metabolism & lipid biology? Please DM for details. Ideal position for recently graduated undergraduates interested in research experience prior to grad school.