🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

Just FYI - they aren’t “saving” money, this doesn’t reduce the debt, it’s just extending the length of time it takes to pay it off (and, in fact, exposes them to more indexation).

Reminder: Victory for Trump is likely to all but end global hopes of staying below 1.5C, our analysis found in March carbonbrief.org/analysis-trump…

Francesca Albanese's Francesca Albanese, UN Special Rapporteur oPt greatest hobby: shredding stupid Western journalists to pieces.

The next presenter is Rhys Grinter Bio21 Institute showcasing his research on "Inhibiting bacteria heme-piracy using de novo designed proteins" 👏 Monash Institute of Pharmaceutical Sciences WEHI (Walter and Eliza Hall Institute) Molecular Horizons @ UOW Australian Research Council

Was nice to get some nice feedback on my work, the poster prize was a bonus! Thanks for organising a nice conference ARC CCeMMP ! 🔬🦠 Thanks also to my supervisor Rhys Grinter for all his support!! Stay tuned for the preprint soon 😊

In this week’s Editors’ Choice piece, we highlight a study by Bayly-Jones and colleagues in nature, showing that the cholesterol-sensing protein LYCHOS contains a plantlike transport protein domain. Read a summary: bit.ly/3O9VgXa

Highlighted today in Cell a great perspective piece about our recent work on LYCHOS. Arun K. Shukla and colleagues raise interesting points about membrane cross talk! cell.com/cell/abstract/…

Computational Design of Metallohydrolases 🚀 New preprint from David Baker!🚀 1. This study introduces RFam, a generative AI-based flow-matching model, which enables atomic-level scaffolding of enzyme active sites without predefined sequence positions or rotamer states,

🦋 danielrfox.bsky.social

The first major body of work from my PhD is now up on BioRxiv! We used AI-designed binders to block the uptake of heme from hemoglobin through ChuA, a heme transporter found in pathogenic E. coli. 🦠🩸🔬 I’m very grateful for my supervisors and all coauthors for their support!

Thrilled to contribute to this exciting project led by Daniel Fox. Congratulations team! We used de novo protein design to block heme piracy in E. coli.

We are excited to share pre-prints describing a successful foray into ML-driven protein design. With Rhys Grinter we designed proteins to potently inhibit CRISPR-Cas13 (doi.org/10.1101/2024.1…) or block heme piracy by pathogenic E. coli (doi.org/10.1101/2024.1…):

Thrilled to see our work on high-resolution #cryoem using a common LaB6 120-keV TEM and sub–200-keV direct electron detector, now online Science Advances. science.org/doi/10.1126/sc… . A collaboration with Gatan Microscopy, @GeorgRamm, and Ramaciotti Centre for Cryo EM.

Thank you again to all the wonderful collaborators for their amazing samples and discussions. @JesseMobbs, Cyntia Taveneau, Daniel Fox, Ziva Vuckovic, Rhys Grinter, Gavin Knott and @Thal_DM.

First Ramaciotti Centre paper of 2025 by our own Hari Venugopal in Science Advances. Check out how to get high resolution #cryoEM on a Microscopy & Spectroscopy 120keV LaB6 Tecnai with a Gatan Microscopy Alpine camera.

Meanwhile our public school P&C had to raise money for fucking shade cloth

Labor has done a dirty deal with the Liberals to not preference the Greens in Macnamara. This now risks the Liberals winning the seat, and bringing Dutton one step closer to the Lodge. Labor voters will be furious they are helping Dutton with preferences.

”If I get an award, I have an opportunity to thank people. I also thank the people who tried to make my life miserable because they made me work harder and become more resilient.” Next week, our podcast returns with conversations featuring our 2024 laureates. In the meantime,

A damning review into ANU's College of Health and Medicine has revealed a dysfunctional culture of bullying, sexism, unfair workloads and nepotism. ab.co/43MN9bu