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Today we’re releasing Chai-1r, an updated version of Chai-1 with full support for restraints. Prompting Chai-1r with prior structural knowledge can boost accuracy by >2x. github.com/chaidiscovery/…

Chai-1r now available for both commercial and non-commercial use! 🤩

I'm excited to share that we're making this technology available for broad commercial use, starting today. It's been amazing to witness the rapid adoption of Chai-1. We can't wait to see all the ways it will accelerate drug discovery.

Super excited to preprint our work on developing a Biomolecular Emulator (BioEmu): Scalable emulation of protein equilibrium ensembles with generative deep learning from Microsoft Research AI for Science. #ML #AI #NeuralNetworks #Biology #AI4Science biorxiv.org/content/10.110…

Excited to announce the general availability of Chai-1 in SAMSON! Like AlphaFold 3, Chai-1 is a state-of-the-art foundation model for biomolecular structure prediction which handles proteins, small molecules, DNA, RNA, glycosylations, etc. One particularly exciting feature is the

Introducing Warp on Windows – the intelligent terminal built for speed, AI, and collaboration. Download today – more on what’s in the box 🧵 warp.dev/windows-termin…

Life update - I have joined Chai Discovery as part of the founding team earlier this year! A rather belated announcement, but I want to take the time to thank all friends, share some reflections, and talk more about things ahead that excite me most. Post: substacktools.com/sharex/EYdWWDAZ

Excited to share details of what we are working on Nudge for the first time today. Our mission is to improve everyday life by developing the best technologies for interfacing with the brain.

We got a robot to clean up homes that were never seen in its training data! Our new model, π-0.5, aims to tackle open-world generalization. We took our robot into homes that were not in the training data and asked it to clean kitchens and bedrooms. More below⤵️

We’ve raised a $130 million Series B led by Kleiner Perkins alongside new investors Nat Friedman/Daniel Gross , Vinod Khosla, and HUMAN CAPITAL — joined by existing investors Founders Fund , DIMENSION, and Brian Armstrong (yes, the cofounders are doubling down). We also raised

We're excited to partner with the UK Government on OpenBind, an effort to create the largest open dataset of drug-protein interactions in history. More data → smarter AI models → better medicines gov.uk/government/new…

Introducing Warp 2.0: the Agentic Development Environment 1️⃣ Top overall coding agent: #1 on Terminal-Bench, 71% on SWE-bench Verified 2️⃣ Agent multi-threading: build features, debug, and ship all at once 3️⃣ The first all-in-one platform for agentic development 🧵 Learn more

Chai Discovery (Joshua Meier Chai Discovery) just released Chai-2, a model for "zero-shot antibody design in a 24-well plate." The most existing result? Chai-2 successfully generated binders for 50% of the 52 targets they assayed (100x better than SOTA)! Some thoughts below:

We’re excited to introduce Chai-2, a major breakthrough in molecular design. Chai-2 enables zero-shot antibody discovery in a 24-well plate, exceeding previous SOTA by >100x. Thread👇

Big thank you to stellar engineering team at Modal, who provided some critical infrastructure for this effort. They are a joy to work with.

Some use cases are cooler than others, and it's safe to say zero-shot antibody design is one of them. Congrats on launching Chai-2!🧬

NewLimit paper just dropped ICML Conference showing our SOTA AI models can predict perturbed cell states. Helps to have the largest primary cell perturbation dataset in the world. Bonus points for one of the first demonstration of active learning in bio.

Nudge is working on one of the most important problems in our lifetime. What an incredible endorsement of their world-class team and rate of progress.