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Very proud LMRL lmrl.org was accepted for a second year at NeurIPS neurips.cc. Can ML accelerate biomedical discovery? From medicines for people, to protein designs that eat plastics, to forecasting viral evolution, to human genetic variation. Come!

Natural seq models are good at predicting pathogenic mutants- often better than wet-lab assays! Jonathan Frazer Mafalda Dias Pascal Notin Debora Marks classify 72,000 variants of unknown significance across human genome (& in total, 4x that in ClinVar!) biorxiv.org/content/10.110…

1/n I'm excited to share our preprint *Large-scale clinical interpretation of genetic variants using evolutionary data and deep learning* biorxiv.org/content/10.110… from a great collab with Pascal Notin Mafalda Dias @AidanNGomez Dr. Kelly Brock Yarin (OATML_Oxford) Debora Marks 🧵

Today we report the use of base editing in patient-derived cells and in mice to correct the most common cause of progeria, the devastating rapid aging disease. Progeria is typically caused by a dominant negative C•G-to-T•A point mutation in LMNA. 1/11 drive.google.com/file/d/1oH4W0z…

Our new paper is out in Nature Chemical Biology where we describe our journey from a #covalent fragment screen to an in vivo active Pin1 inhibitor. nature.com/articles/s4158… Below is a musical abstract guest-starring Uri Alon and a tweetorial 1/n

Can one anticipate viral evolution enough to support timely intervention? Check out our new preprint on forecasting antibody escape biorxiv.org/content/10.110… With Sarah Gurev Pascal Notin Noor Youssef Nathanael Rollins Chris Sander aka cscbio Yarin (OATML_Oxford), Debora Marks, 🧵1/10

We’ve updated our EVEscape paper with more SARS2 retrospective evaluation and potential use-cases! biorxiv.org/content/10.110… Collaborators Sarah Gurev Pascal Notin Noor Youssef Nathanael Rollins Chris Sander aka cscbio Yarin (OATML_Oxford), Debora Marks, 🧵1/4

But if we show all the gene knockouts ordered by genomic position, a curious pattern emerges: CRISPR knockouts look more similar to KOs on the same chrom. arm than to KOs on other arms –producing a striking image of a genome-wide CRISPR map in which genome structure is obvious!

Excited to debut our work: ML methods that accelerate the development of proteins of interest into full-fledged therapeutics. By making proteins safer, faster, we hope to expand the space of therapies in the clinic!

Announcing popEVE - a deep generative model of the human proteome that reveal over a hundred novel genes involved in rare genetic disorders medrxiv.org/cgi/content/sh… Jonathan Frazer Aaron Kollasch @H__Spinner Courtney Shearer Mafalda Dias Debora Marks explore at pop.evemodel.org

New preprint out! Babies are born to breastfeed. While 50% of lactating persons struggle to make enough milk, there are no FDA-approved drugs to enhance lactation. We engineered a long-acting prolactin, Prolactin-XL, to enhance milk production. bit.ly/prolactin-XL 1/14

New microscopy technology enables nanoscale imaging of centimetre-scale tissues, making it possible to image the entire expanded mouse brain at cellular and subcellular resolution. #ReviewedPreprint elifesciences.org/reviewed-prepr…

Want to catch up with the rapid progress in ML for functional protein design? Not sure where to start? Check out our review in Nature Biotech! #ProteinDesign #NatureBiotechnology #Cover

How can we use #GenerativeAI for #ProteinDesign? - check out work from our labs Debora Marks and Yarin nature.com/articles/s4158…