Exciting work by @damwahida/@MonicaYabal & ZeissigLab highlights the power of monogenic IBD to understand the link between epithelial dysfunction, the microbiome🦠, and intestinal inflammation🔥. Delighted to contribute a Focus article in Science Immunology🤩: science.org/doi/10.1126/sc…

Outstanding work by Uhlig lab - co-first authors sumeet chrissyb Christopher S. Smillie #monogenicIBD #VEOIBD American Gastroenterological Association (AGA) An integrated taxonomy for monogenic inflammatory bowel disease gastrojournal.org/article/S0016-…

#monogenicIBD science! 2 papers in Science Immunology - @MonicaYabal and Sebastian Zeissig - XIAP and IBD - Paneth Cells Editorial by Uhlig Aline Azabdaftari Paneth cell dysfunction and the intestinal microbiome in XIAP deficiency …ence-org.myaccess.library.utoronto.ca/doi/10.1126/sc…

We could not be more excited to see our #opensource AID consensus published on #WorldDiabetesDay! 48 co-authors, 25 countries, and almost 2 years of fantastic work. #WeAreNotWaiting & #PayItFoward!

Want to use modern neuroscience to understand Parkinson’s Disease and DBS, but not familiar yet with the available tools? Check out our new review highlighting different ephys and optical approaches and how they have pushed the rodent PD/DBS field forward. doi.org/10.1016/j.expn…

1/ In Journal of Experimental Medicine, Qian Zhang, Daniela Matuozzo, @Jeremie_LP, Rice Lab, Shen-Ying Zhang, Aurelie Cobat, report recessive inborn errors of type I IFN immunity in 12 of 112 children (10.7%) who were hospitalized for COVID-19 pneumonia (doi.org/10.1084/jem.20…).

Happy to share that my work on the beneficial role of ROS on stem cell niche regulation has been published !! #ROS #Stemcell #IBD #Nox1 Congrats to all authors!! Judy Cho Ling-shiang (Felix) Chuang, Ph.D. Shikha Nayar Huaibin Mabel Ko Aline Azabdaftari Thaddeus Stappenbeck, MD, PhD gut.bmj.com/content/early/…

Hermansky-Pudlak syndrome causes Crohn’s disease-like inflammation, lung fibrosis, and macrophage lipid accumulation. Here researchers show dysregulated immunometabolism contributes to the impaired anti-microbial immunity and inflammation: nature.com/articles/s4138…

Human TLR4 deficiency Capitani et al. jacionline.org/article/S0091-… accompanied by Li et al describing Human MD2 deficiency doi.org/10.1016/j.jaci… Congratulations to Daniel Kotlarz, Christoph Klein and VEOIBD collaborators.

Check out new pre-print 👇 A longitudinal scRNAseq therapeutic atlas of anti-TNF in IBD biorxiv.org/content/10.110… Super fun collab with dream team Christopher Buckley, Holm Uhlig, Simon Travis & the outstanding clinical fellow and DPhil student @TomThom03928021! 💫

🧠 Curious about how neurons are wired in the human cortex? Our Science Magazine study tested over 7,000 connections and revealed key differences from rodents: "Directed and acyclic synaptic connectivity in the human layer 2-3 cortical microcircuit". 🧵👇science.org/doi/10.1126/sc…