In a recent paper, Shen et al. reported that most synonymous mutations in yeast genes were strongly deleterious. In a new preprint, we argue that this result is largely or entirely artifactual and arose from a lack of appropriate controls. biorxiv.org/content/10.110…

Ooof

50 years of RNA Yale University a symposium in honor of Joan Steitz took place Aug. 19. All of us are grateful to Joan for her mentorship, friendship and leadership. Pic is of @NCISandraWolin and me in front, with Tom Cech's kick-off slide. Tx to Haifan Lin for pic. @YaleMBB@YaleGenetics

this! the underpinning ideas can be compelling but the complete failure to track uncertainty is so disappointing.

ribosomal protein paralogs can have different functions during stress(!) makes me wonder what else these they can do..?

All the eIF bind ’n seqs!

Curious about compensation in biotech and pharma? This massive spreadsheet of crowdsourced data from r/biotech is a fantastic resource capturing types of roles, types of orgs and experience levels across various geographic locations -docs.google.com/spreadsheets/d…

Here’s a hot take that might lose me some friends 🤷🏻‍♀️ but it seems obv: Grad students are the lifeblood of academia. We must raise their stipends above the poverty line so they can focus on research instead of survival. When the union strikes, we (PIs) should strike with them.

One #CSHAsia meeting at two venues 🇯🇵🇨🇳 having three groups of participants using four ways of interactions to share the latest discoveries in #RNA research in five days. #RNAsplicing #sncRNA #lncRNA #mRNA #rRNA #rRNA #miRNA #CircRNAs #RNAstructure #RNP #RNAtherapeutics

One of my favorite @nature covers for this week’s issue

Happy Valentine’s Day!

On Friday, March 10th in Hope 216, Austin Draycott, Gilbert Lab, will be defending. The title of his defense is “Canonical and Non-canonical Functions of Dihydrouridine Synthases in Health and Disease.” Refreshments served at 1:45 pm and defense will start at 2:00 pm.

Woohoo!

You can meet with us and the other participating startups on 10.11 during a Networking Mixer with MassBio's innovation ecosystem. Register here: massbio.org/events/listing… the-massbiodrive-f23-cohort/ (3/3)

woohoo!

Enormous congrats to my remarkable cofounder, Cole Lewis for earning a spot on the Forbes Under 30 Healthcare list! Working with Cole to translate our science into therapeutics has been a wild ride so far, and I'm looking forward to building cloverleaf bio's future together!

REVALIA BIO “HUMAN ORGAN RESEARCH” AWARD: 2023 Yale University Life Science Pitchfest Wendy V. Gilbert (Wendy Gilbert), PhD, Professor of Molecular Biophysics and Biochemistry Project: Developing therapeutic tRNAs to revolutionize cancer therapy

Join us Friday, May 3rd at 2PM in Hope H-103 (or via zoom) for Cole Lewis' thesis defense titled "Maximizing Therapeutic Protein Yield Through 5' UTR Optimization"