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sisters paper got published today in the Science Magazine your work is beyond me, but congrats Aakriti Jain — this is huge! science.org/doi/10.1126/sc…

Aakriti’s research is already making a major impact, and she’s ready to launch her own creative & innovative lab. Departments hiring in thie signaling/metabolism/quality control areas & more—she’s one to watch!

Amazing story from #MolecularTherapeutics Molecular Therapeutics Initiative faculty Roberto Zoncu with lead author Aakriti Jain describing membrane protein degradation in the lysosome. Congratulations!! science.org/doi/10.1126/sc…

Leucine aminopeptidase LyLAP enables lysosomal degradation of membrane proteins | Science science.org/doi/10.1126/sc…

Happy to have contributed in a small way to this spectacular study from Aakriti Jain and Roberto Zoncu identifying LyLAP as a protease for hydrophobic TM domains in the lysosome. Upregulated in PDAC, LyLAP safeguards lysosomes from membrane damage. science.org/doi/10.1126/sc…

An incredible tour de force in biochemistry and cell biology by superstar Roberto Zoncu lab postdoc Aakriti Jain LyLAP - a new lysosomal protease responsible for degrading integral membrane proteins in highly phagocytic cells like #PDAC cells. 🙌✨ science.org/doi/10.1126/sc…

Very impressive work. Congratulations to all

What a masterpiece by Aakriti Jain, Roberto Zoncu, and the team! And, the storytelling - simply amazing! Leucine aminopeptidase LyLAP enables lysosomal degradation of membrane proteins | Science science.org/doi/10.1126/sc…

Regina is the newest superstar in CRI. This would be a great lab to train in!

Our SIFI story just came out! Great teamwork Diane Haakonsen, Michael Heider, Sam Witus from the Rapé Lab and our collaborator Alex Zelter at UW. nature.com/articles/s4158…

Excited to share our latest review "Lysosomal Repair in Health and Disease". We summarized how cells repair lysosomal damage via 4 distinct strategies and discussed the implications for aging, neurodegeneration, cancer, infection, and more. Open access: onlinelibrary.wiley.com/doi/10.1002/jc…

Thrilled to have our story on the regulation of lysosomal lipids out in Cell Metabolism! The work was led by two outstanding grad students Jess Davidson and Raghav Jain probing mechanistic control of energy expenditure HHMI UW–Madison Biochem

Last week, Mosaic won 1st place in the AI demo competition at SaaStr Annual — beating out hundreds of other AI startups in one of the world's largest software conferences. Beyond the prizes that come with winning, presenting at SaaStr was a high visibility opportunity that put

My lab is recruiting a postdoc fellow to characterize new biochemical pathways that control taurine and glucose metabolism. Email me at [email protected] to apply! Please help RT🙏 Long Lab Judith Simcox PhD UW–Madison Biochem

Incredibly creative and super important study from Gilles Rademaker and Rushika M. Perera showing how where cells get their cholesterol from can impact PDAC metastasis!

My lab's first paper is out in nature. We show that lipoprotein uptake protects tumors from ferroptosis by delivering the lipid antioxidant α-tocopherol. Surprisingly, tumors use sulfated glycosaminoglycans—not canonical receptors—to capture lipoproteins. nature.com/articles/s4158…

When #AlphaFold2 came out, we wondered: Could it help us understand how enzymes evolve? So we tried it—and it worked! nature.com/articles/s4158…