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Fantastic paper showing that MRI derived T1/T2 ratio correlates with NMDAR encephalitis clinical manifestation, and can therefore act as biomarker. 👇 🔎 jnnp.bmj.com/content/early/… Fab work by authors @timjhartung, Carsten Finke et others

DPUK study led by Ivan Koychev uses of #MachineLearning in generating ATN risk prediction among pre-dementia individuals. The team investigated whether ATN phenotype can be predicted using routinely collected research cohort data. zurl.co/7vWc

We've over 9,000 high characterised individuals in DPUK’s Great Minds register. Each has regular memory assessments. All can be recruited for pioneering studies. We'll start to make break-throughs and stop #dementia in its tracks. More info: zurl.co/rHVG

NEWS: Lymph node research pioneers’ new approach to vaccine design for the most vulnerable NDORMS has received its first volunteers as part of the LEGACY03 trial to improve vaccine design for different age groups. medsci.ox.ac.uk/news/lymph-nod…

Pleased to announce number 2 has been released: led by the tireless Sophie Binks and @micheleveldsman tinyurl.com/4ncmcac2 Bottom lines: > despite low mRS, LGI1 patients have multiple residual deficits > there is high carer burden > fatigue best correlates with QoL

…..And as promised…. Thrilled to announce publication of our paper PNASNews describing the #CSF B cell profiles in three patients with LGI1 or CASPR2-Ab #encephalitis pnas.org/doi/10.1073/pn… Well done to all especially @JakobTheorell and RubyHarrison Details to follow…. 👇🏿

Online remote #cognitive assessment in patients with autoimmune #encephalitis can detect subtle cognitive deficits - new study in eClinicalMedicine – The Lancet Discovery Science by Masud Husain Mayo Florida AutoImmune Neurology Group Sanjay Manohar and team. thelancet.com/action/showPdf…

DPUK's Ivan Koychev co-authors BJPsych Journals paper exploring treatment of rare type of autoimmune encephalitis that causes potentially reversible cognitive and psychiatric presentations similar to progressive #dementia Read in full: zurl.co/cvFY #BJPsych

Read the #openaccess #BJPsych article here: tinyurl.com/4c98t3jp Cambridge UP - Psychology & Psychiatry Royal College of Psychiatrists

New paper! NMDA receptors play a dual role in human WM. We studied patients with a rare antibody to NMDA receptors, and found impairments in both associative binding and maintenance. jneurosci.org/content/early/… 1/4 🧵

Now do academic psychiatry Royal College of Psychiatrists I was told recently there are 280 of us.

“Peer reviewers: chill out and don’t let the power go to your head.” timeshighereducation.com/opinion/peer-r…

John-Arne Røttingen Wellcome The problem isn't feeding the pipeline of ECR's with PhD opportunities It is career progression, the rightward shift in independence by age, & a profligate waste of talent that is typically 10+ years in development - until the system can't support it x.com/cardiacpolymat…

Online now! Cervical lymphatics drain CSF and clear metabolic waste from the brain. Du et al., show using 2P-OPTIC that these are disrupted in aging due to reduced pumping. Restoring cervical lymphatic function with PGF2a rescues brain clearance. doi.org/10.1038/s43587…

Why we need a revolution in clinical research. New editorial Brain academic.oup.com/brain/article/… National Institute for Health and Care Research Medical Research Council UK Research and Innovation Wellcome Wes Streeting

#JNeurosci: Results from Dor, Adam, John P Grogan, Sanjay Manohar, et al. demonstrate that patients with NMDA receptor-antibody encephalitis are an ideal model condition to study roles of receptors in human cognition and suggest NMDARs are critical for both maintaining

Check it out ➡️ tinyurl.com/2s3cf3wu …….our first foray into neurodegeneration. 🧠 Work led by the fabulous Adam #Amyloid & #tau are concentrated in human cervical lymph nodes (CLNs) and CLN tau levels fall with age.

Very important work, supporting the idea of CSF drainage by meningeal lymphatics in humans.

Al-Diwani et al. show that biomarkers used in dementia diagnosis are present at higher levels in human cervical lymph node aspirates than in blood. Sampling cervical lymph nodes could enable minimally invasive assessment of brain clearance. tinyurl.com/3zsa4rn7

👉Riccardo De Giorgi and colleagues present a comprehensive analysis of pre-clinical and clinical studies examining the role of glucagon-like peptide-1 receptor agonists in #cognitive and #mental disorders. Oxford Psychiatry, University of Oxford nature.com/articles/s4422…