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Its a good day for #IowaHawkeyes @iowamed Internal Medicine at Iowa University of Iowa Health Care @DaretoDiscover when three of my mentees receive AHA Research AHA Science Career Development Awards. Check out screen shot from my Proposal Central dashboard! Acknowledging co-mentors Eric Taylor @IowaPSTP

Exciting new work with @KevinCa63443270 featuring reversible metabolic changes in muscular dystrophy!

Ever wondered how quickly mouse tissues need to be frozen to preserve the in vivo metabolome? Immediately after disrupted perfusion. We show here that this applies to the broad metabolome, between-genotype differences, and 13C-isotopologue distributions. biorxiv.org/content/10.110…

Important methodological contribution for anyone doing tracer/metabolomics studies. "Our findings demonstrate that capturing the in vivo tissue metabolome requires immediate post-dissection freezing" The pAMPK data in Fig 1 is very illustrative.

Excited to see this out in its final form Molecular Metabolism. Big thanks to my co-authors Nick Borcherding and mentor Eric Taylor.

The first paper of the Wernimont Lab is finally out! In this work, we highlight the importance of mitochondrial citrate in regulating trophoblast differentiation. ⁦UMN Medical School⁩ nature.com/articles/s4159…

New! Online now: A hierarchical hepatic de novo lipogenesis substrate supply network utilizing pyruvate, acetate, and ketones dlvr.it/TFqJG5

New! Online now: Bempedoic acid suppresses diet-induced hepatic steatosis independently of ATP-citrate lyase dlvr.it/TFrR4n

A hierarchical hepatic de novo lipogenesis substrate supply network utilizing pyruvate, acetate, and ketones dlvr.it/THG9YJ

An initial rendition of my postdoctoral work in the Mair lab is out on biorxiv now. biorxiv.org/content/10.110…

How do cells respond to physiologically high O2 levels? In research just published in Science Advances (science.org/doi/10.1126/sc…), we investigating respiratory epithelia since their contact with air exposes them to some of the highest O2 levels in the body. In work led by

FGF21 analogs reduce liver steatosis and fibrosis in patients with MAFLD/MASH. Our new paper provides insight into the mechanisms for these effects: cell.com/cell-metabolis… OU Health Harold Hamm Diabetes Center OU Health