Gratifying to see that Calico has put their eIF2B activator into the clinic! From UC San Francisco bench to bedside (with some luck). calicolabs.com/press/calico-a…

Big congrats to Ryan Gonciarz who made the most of his time while UC San Francisco labs were shuttered. His second review article written during COVID is now out in Curr. Opin. Chem. Biol. doi.org/10.1016/j.cbpa…

Thanks to SNMMI for this nice press release highlighting our recent work developing "ferronostics" with Adam Renslo Davide Ruggero UCSF Helen Diller Family Comprehensive Cancer Ctr UCSF Imaging Novel Imaging Agent Identifies Biomarker for Iron-Targeted Cancer Therapies - SNMMI: snmmi.org/NewsPublicatio…

Congrats to first author Ning Zhao, former Renslo lab members Ryan Muir and Ying-Chu Chen, and the rest our collaborators in the Michael Evans lab!

Honglin Jiang, Eric Collisson, Adam Renslo et al. UC San Francisco report that oncogenic KRAS signaling induces a therapeutically targetable accumulation of Fe2+ in #KRAS-driven #SolidTumors. bit.ly/34t17DD Ryan Muir Michael Evans UCSF School of Pharmacy #Metabolism

Iron out KRAS-driven cancer | Journal of Experimental Medicine | Rockefeller University Press rupress.org/jem/article/21… Our paper targeting KRAS-driven ferroaddiction is out in JEM! Congrats to Honglin, Ryan Muir, Ryan Gonciarz, Eric Collisson, and the rest of the team!

Treating Tough Tumors by Exploiting Their Iron ‘Addiction’ ucsf.edu/news/2022/03/4…

Big contrats to first author Kaitlin Hulce in the Craik Lab at UCSF and the rest of the team. This one was a long time in the making. A first step towards finding a new way to inhibit these unusual viral proteases. sciencedirect.com/science/articl…

Are you a synthetic organic chemist seeking a postdoc in SBDD and drug discovery? Join the Renslo lab and collaborate with Fujimori Lab UCSF James Fraser (A$AP J) Kevan Shokat Craik Lab at UCSF DeGrado Lab to discover new antivirals as part of the AVIDD Research Team UC San Francisco. qcrg.ucsf.edu/jobs-qcrg-avid…

Happy to share a preprint describing our new probe FeAL-1 for Bioluminescence in vivo Imaging of Labile Iron in Xenograft Models and Liver SSRN @cellpressnews Sneak Peek papers.ssrn.com/sol3/papers.cf…

All the hubbub over Twitter has me on the site again, against my better instincts... sigh. Anyway, check out our latest preprint here: papers.ssrn.com/sol3/papers.cf…

Check out our latest work on Caspase-6 with ArkinLab UC San Francisco ChemRxiv doi.org/10.26434/chemr…

RSL-3 and other GPX-4 inhibitors have two covalent binding sites on the protein. Weird and cool.

Thrilled to share a chemrxiv describing our systematic study of heteroarene-aryl stacking with 30 molecular glues for caspase-6. Our first collaborative work with Steven Wheeler @WheelerCompChem doi.org/10.26434/chemr…

Enjoying the blizzard in SLT while preparing for study section this week.

Check out our latest – an empirical and computational study of diverse heteroarene–tyrosine stacking interactions in solution. This was a rewarding multidisciplinary academic-industry collaboration. Much more to come with this system! tinyurl.com/3yf3ekb2

A team led by Adam Renslo UC San Francisco studied the stacking energies of 30 distinct heteroarenes using SPR, QRET, and high accuracy computation. Read more in #JMedChem ➡ go.acs.org/5Ee

Using luciferin-based probe FeAL-1 we and our collaborators UC San Francisco and Merck SSF compared labile iron levels in healthy mouse liver with that in pancreatic ductal adenocarcinoma xenografts. Hepcidin treatment elevated LIP in both tissues. Congrats to the team!

Big congrats to the whole team, but especially first author and former joint postdoc Parker Deal who saw this multi-year effort through to a really satisfying result. This approach opens the door to more small molecule modulators of K2Ps.