🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

2/8 🔬 Why macrophages? They are known to be key players in coronary artery disease (CAD): they ingest harmful lipids like oxidized low-density lipoprotein cholesterol, and exhibit a foamy phenotype within atherosclerotic lesions. These cells are also remarkably plastic!

3/8 🧩 The puzzle? CAD is largely heritable. Many genomics studies have integrated GWAS results to prioritize causal variants and the cellular context in which they operate. Surprisingly, no genetic evidence was found for macrophages, like a failed positive control in your PCR🤔

4/8 🗺️ We believe that such false neg results are due to the low resolution of the cis-regulatory element (CRE) map. Using #singlecell #multiome, we built a genome-wide macrophage CRE map, linked 121 CAD risk variants to 56 genes, and revealed an AP-1-centered regulatory network!

5/8 💡Inspired by the sc-Linker paper and many others, we adapted the popular LDSC method to partition heritability into single-cell annotations and evaluated the disease relevancy in each macrophage subpopulation. This led to a novel CD52-hi lipid-handling subpopulation......

6/8 💥Functionally, these CD52-hi macrophages display activated lipid metabolism pathways and accumulate less lipid upon exposure to oxidized low-density lipoprotein cholesterol. In vivo, they represent a subset of the foamy TREM2-hi lipid-associated macrophage cluster

7/8 🎯 Mechanistically, we have shown that the transcriptional regulatory machinery for a CAD risk variant, rs10488763, is specifically activated in lipid-handling macrophages. Also, for the first time, we have implicated its target FDX1 as a disease gene for atherosclerosis!

GLP-1 receptor agonists, which are effective for weight loss, can cause substantial muscle loss. A Comment in The Lancet Diabetes & Endocrinology discusses the effects of GLP-1 receptor agonists on skeletal muscle mass: hubs.li/Q02WgC490

NEW: The first human tissue samples from Oxford's Space Innovation Lab (SIL) have been launched and are on their way to the International Space Station, where they will be used to study the effects of space microgravity on the human ageing process.

Ox-LDL induces a non-inflammatory response enriched for coronary artery disease risk in human endothelial cells biorxiv.org/cgi/content/sh… #biorxiv_genomic

Call for Submissions! Circulation Research welcomes the submission of Research Letters to accompany a Compendium on "Interorgan Crosstalk in Heart Failure and Cardiometabolic Diseases". Details here: bit.ly/3AY9W8Y Initial submissions are due no later than January 24, 2025

My editorial on epigenetic & metabolic reprogramming driving post-MI fibrosis now out in Circulation AHA Science

ISHR-ES annual meeting Birmingham 2026.🇬🇧 Call for symposium proposals! We invite ISHR members to submit symposium proposals for the 2026 ISHR-ES meeting. Please complete the proposal form at ishr-europe.org and return it to [email protected] 😀🤝❤️#CardioResearch

NIHR Birmingham Biomedical Research Centre NIHR Cambridge Biomedical Research Centre Great Ormond Street Hospital for Children NIHR Leeds BRC NIHR Southampton BRC (6/13🧵) NIHR Oxford Biomedical Research Centre - First aerosol TB vaccine trial launched in Oxford 💉 oxfordbrc.nihr.ac.uk/oxford-launche…

Anyone who publishes a plan to build a virtual cell in Cell is constitutionally incapable of actually building one.

#APS2025 attendees: Day 1! You should have gotten your first News Update daily email with program highlights. Use the Summit app for your schedule and follow us on social media, using the meeting hashtag and #WeArePhysiology. We want to see what YOUR meeting looks like!

We would like to thank departing ISHR_ES council members Mauro Giacca, Gregoire Vandecasteele, Diederik Kuster for their contributions to the council over the years 👏🏻👏🏻👏🏻Mauro Giacca Sean Davidson Sean Davidson Monika Gladka Christoph Maack #ISHR_Nara