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A BLAST from the past: revisiting blastp's E-value | bioRxiv biorxiv.org/content/10.110…

To help address the antimicrobial resistance crisis, there are hundreds of very promising antibiotic candidates found hiding in our microbiome cell.com/cell/fulltext/… Cell @delafuenteupenn

I'm going to keep saying this until someone proves me otherwise: AlphaFold(2, 3, 10000, whatever) or any structure prediction tool will not generalize to protein conformations if its training is optimized to "ground truth" structures in the PDB! Crystallized or cryo-EM structures

Our team's efforts in bio-imaging in live animals has been published on Science. If you are interested in our work, feel free to reach out to me and I am happy to chat and discuss future potentials! science.org/doi/10.1126/sc…

Why are bioinformatics results so full of false positives? I've been thinking about this for a few years: the incentives in the field are to produce false positives (link in next tweet)

🤩 Abstract submission and early registration for the #ISEV2025 Annual Meeting are now open! 🎼 Submit your abstracts before November 3rd: buff.ly/4e8W0Xu Eva-Maria Albers An Hendrix Edit Buzas Lucia Languino LeeRetinaLab@USC

Gut bacteria identified which can degrade IgA. Read more here science.org/doi/10.1126/sc… and in this Perspective science.org/doi/10.1126/sc…

It's Nobel week, so—after a break last year when this account became a Karikó stan account—I am reposting my annual plea to give Lipman and Myers a Nobel Prize for creating BLAST substack-proxy.glitch.me/articles/luisp…

A core microbiome signature as an indicator of health | Cell Metagenomics on a high-fiber dietary intervention plus reanalysis of 26 case-control studies. Identified a set of stably correlated genome pairs perturbed by interventions and diseases cell.com/cell/fulltext/…

Looking for a postdoc position in nuclear #mechanobiology, with a strong interest in microfluidics, device design, fluorescence microscopy, and image analysis? Check out our opening: bme.cornell.edu/bme/job-openin… If you are attending #BMES2024, we can meet there. Please RT.

I had to write. It's been 2 years since I moved back to India. Here's I what I think about moving abroad. orkohunter.net/blog/why-dont-…

Spatial structure shapes the host-microbiome interactome. Our new method to map the host-microbiome interface at high-res, now on bioRxiv! Co-led with lena & David McKellar collab between the Iwijn De Vlaminck & Ilana Brito labs doi.org/10.1101/2024.1… A thread⬇️

The bacteria in your gut depend on where you are in the social network. And the microbes within us treat our social networks as the extended environment in which they thrive. They can spread from person to person. New #HNL work out today in nature. 1/

"Gut microbiome strain-sharing within isolated village social networks" nature.com/articles/s4158… with Francesco Beghini, Jackson Pullman, Marcus Alexander, MD, PhD, Shiv, Drew Prinster (same @ other app), Adarsh Singh, RM Juárez, Edo Airoldi, Ilana Brito #HNL 2/

Ticks make their own bioglue in their saliva to help them attach to and seal skin! It's an IDP, like the freshwater mussel adhesive I previously posted. No data yet on how it compares in terms of performance, so I guess we'll have to make it! biorxiv.org/content/10.110…

In case you missed it - out now in nature: Gut microbiome strain-sharing within isolated village social networks Nicholas A. Christakis Francesco Beghini Jackson Pullman Marcus Alexander, MD, PhD Shiv Drew Prinster (same @ other app) Adarsh Singh Edo Airoldi Ilana Brito nature.com/articles/s4158…

"Gut #microbiome strain-sharing within isolated village social networks," a nature study Nicholas A. Christakis Francesco Beghini Marcus Alexander, MD, PhD Shiv Drew Prinster (same @ other app) Adarsh Singh Edo Airoldi Ilana Brito #Microbiota👇 nature.com/articles/s4158…

Congrats to Cornell Engineering Cornell BME faculty Ilana Brito , named a 2024 Pew Health Innovation Fund Investigator, working with Gabriel Victoria, Ph.D. of The Rockefeller University to unravel interactions between immune cells and the gut. bme.cornell.edu/news/brito-nam…

Immunoglobulin A controls intestinal virus colonization to preserve immune homeostasis Cell Host & Microbe cell.com/cell-host-micr… Bana Jabri