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Check out our last publication on ischemic mitral valve regurgitation in human patients using an integration of Echo/Cytometry/Proteomics data! Elena Aikawa Livia Passos, Ph.D sasha Dakota Becker-Greene frontiersin.org/article/10.338…

Vesseg, a tool for deep learning-based atherosclerotic plaque quantification in mouse histopathology images, is now available at ow.ly/6cHB50FS3Pc. JMM Jan Larmann 🇪🇺👨‍🔬🧪🏢 Jens Kleesiek ow.ly/eGYC50FS3P9

#MitralValve #EndMT A quantitative multi-modality analysis (TTE, proteomics, IHC) of 17 #IschemicMitralRegurgitation patients provides solid evidence for MV EndMT😎 Dr. Adrien Lupieri & Elena Aikawa labs Frontiers in Cardiovascular Medicine 2021 Lupieri Adrien, PhD Elena Aikawa frontiersin.org/articles/10.33…

The #Mechanobiology of Endothelial-to-Mesenchymal Transition in #CardiovascularDisease A very nice review on the impacts of Shear, Stretch & Stiffness on Vascular+Valvular #EndMT😎 Dr. Jeffrey J. Hsu lab Frontiers - Physiology 2021 Jeff Hsu, MD, PhD frontiersin.org/articles/10.33…

Excited to share our latest tool, #VALIS Virtual Alignment of pathoLogy Image Series - it’s been years in the making by the talented Chandler Gatenbee! It automatically aligns serial image slices from immunohistochemistry, immunofluorescence & much more. Here’s a cool gif! #AndersonLab

Calcific aortic valve disease: from molecular and cellular mechanisms to medical therapy. A State of the Art Review in #EHJ European Society of Cardiology #CardioTwitter #aorticstenosis #TAVI academic.oup.com/eurheartj/adva…

Hey tweeps! I am elated to present our new paper @nature to welcome 2022! One of the most fun, concept-rich papers coming out from our lab so far 🧵👇👇 Behavioural immune landscapes of inflammation disq.us/t/4451l3g

Novel vascular disease genes identified from Region-specific single-cell transcriptomics of🐭Aorta Carotid vs Ascending+Arch vs Descending MCAM-/-;apoE-/-🐭are more susceptible to Angiotensin II-induced aortic catastrophe Arispe Lab Research Square 2021 researchsquare.com/article/rs-951…

1/100 children are born with a heart defect, and this research using IMPC data offers a first step towards validating human sequencing studies! 705 genes linked to congenital heart disease, in a groundbreaking paper published - on the cover of Nature Cardiovascular Research! go.nature.com/3gTRD75

Want to know more about calcific aortic valve disease? State-of-the-art review summarizes mechanisms and potential therapeutic targets. doi.org/10.1093/eurhea… #VHD #aorticstenosis #cardiotwitter European Society of Cardiology Journals European Society of Cardiology

Online today, a study by Nicholas Leeper’s team shows that #statins reduce the “‘don’t-eat-me” molecule #CD47 thus amplify #macrophages #phagocytic capacity and amplify the effect of pro-#efferocytic therapies in #atherosclerosis Stanford Medicine | nature.com/articles/s4416…

Are you confused by innate lymphoid cells? Looking for some guidance? Today is your lucky day! Here, we provide the hitchhiker's guide to innate lymphoid cells - leading you through ILCs across all tissues of the body. Enjoy the journey! #42 tinyurl.com/32y9h2r5

We are thrilled to see our new paper out nature! (nature.com/articles/s4158…). We generated a spatially resolved single-cell multi-omics atlas of human myocardial infarction from 23 patients, spanning multiple tissue regions, including over 200k nuclei and 28 spatial samples. 1/n

🎄🎁 The artist Lupieri Adrien, PhD

Sortilin: a type I membrane glycoprotein as a novel key player in calcific aortic valve disease pathophysiology! academic.oup.com/eurheartj/adva… #aortic #valve #sortilin #calcification #omics #fibrosis #cardiotwitter #EHJ European Society of Cardiology Journals European Society of Cardiology

Lupieri Adrien, PhD presenting on sex-dependent effects of Sortilin on Vascular Calcification at #VascularDiscovery2023.

Lupieri Adrien, PhD from Elena Aikawa’s lab presents an interesting study in #VascularDiscovery23 showing the importance of incorporating sex differences in pre-clinical therapeutic models. Our studies should reflect the population being treated. Brigham and Women’s Cardiovascular Life Science AHAMeetings AHA Science

Macrophages mess with ❤️ rhythm ⚡️ transcriptomics and protein data describe 3-fold expansion of these leukocytes in patients with atrial fibrillation. Among the top expressed genes: osteopontin (SPP1), catalyzing atrial fibrosis and inflammation ❤️‍🔥 science.org/doi/10.1126/sc…

Exciting breakthrough in understanding how endothelial cell respond to shear stress delaying dysfunction and atherosclerosis via a PI3KCIIa-dependent autophagy Lupieri Adrien, PhD ahajrnls.org/41X0eN7