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I'm excited to share our findings on a metal-dependent specificity switch for #CRISPR-Cas12a! We profiled the specificity of Cas12a at four Mg2+ concentrations and observed striking differences in mismatch tolerance at lower, physiological conditions 1/n biorxiv.org/content/10.110…

We've published a thing! STOKED to be announcing a new student-led paper in collaboration with Genes in Space, The Boeing Company, ISS National Lab, Michael C. Jewett, Ally Huang, PhD and others. TL;DR We've used cell-free tech to make biosensors in outer space! 🧵

Designing allosteric biosensors toward non-native ligands has been a longstanding challenge. We developed Sensor-seq which combines phylogeny-guided design together with deep sequencing readout of function to create new biosensors for several molecules. biorxiv.org/content/10.110…

Northwestern CSB preprint! Polymerase Strand Recycling (PSR) - new approach to signal amplification in #cellfree #synbio. Detect RNAs, boost sensitivity of biosensors, and much more! bioRxiv by @Jenni_Li_407 Kirsten Jaeyoung Jung CapdeviLAB biorxiv.org/content/10.110…

I honestly do believe that the 2024 French Open is the most open a major tournament has been in a LOOOOOONG fucking time. Alcaraz- injured Sinner - injured Nadal - just about done Djokovic - unwell Ruud - Ruud Medvedev - clay Rune - Mouratoglou Rublev - brain Zverev - jail

I am happy to share that our efforts in SYBORG to integrate metabolism with TXTL to build self sustaining life like systems got one step closer. Now out in Science Magazine 🥳 science.org/doi/10.1126/sc…

Excited to share our work published in Science Magazine today answering the question: “Where does Cas13 come from?” science.org/doi/10.1126/sc…

Excited to share 'frugal' CRISPRkit, a gene editing tool for K-12 education! Developed almost entirely by high school and undergrad students, led by Marvin & Matthew, this kit brings hands-on CRISPR experiments to classrooms to explore genome engineering without equipment. (1/2)

The newest members of the two handed backhand club… Dimitrov, Tsitsipas, Shapovalov, Thiem, Eubanks, Wawrinka, Musetti, & Dan Evans The funniest thing you’ll see all day 😂😂😂

Exposure to heavy metals is a new risk factor for cardiovascular disease sciencedirect.com/science/articl…, highlighting yet another reason for why we need to be able to easily sense heavy metals in drinking water. #Cellfree diagnostics may offer one path. pubs.acs.org/doi/10.1021/ac…

The "test" phase of #syntheticbiology research is slow. Holly Ekas Ashty Karim The Lucks Lab Adam Silverman Brenda Wang Northwestern CSB speed this phase up by developing validation strategies for #cellfree workflows ACS Synthetic Bio Editor's choice pubs.acs.org/doi/10.1021/ac…

As a model, we rapidly generate and assay libraries of 127 MerR and 134 CadR transcription factor variants in 3682 unique CFE reactions in less than 48 h to improve limit of detection, selectivity, and dynamic range for mercury and cadmium detection.

How can we more rapidly develop cell-free biosensors for the detection of chemical compounds such as toxins and human health biomarkers? The Lucks Lab Ashty Karim Northwestern CSB biorxiv.org/content/10.110…

Highly multiplexed design of an allosteric transcription factor to sense new ligands doi.org/10.1038/s41467…

Meet CATALOG Studio—your web app for everything DNA computing. Harness the energy-efficient computing power of DNA with just a few clicks on the easy-to-use platform. Launching 2025! 🧬💻#techinnovation #dnacomputing #ComingSoon

How can we develop ways to make medicines when and where people need them? For everyone? #cellfree systems can help. We demonstrated scalable synthesis of T7 RNA polymerase, a component in mRNA vaccine synthesis, at the 1L scale bioRxiv biorxiv.org/cgi/content/sh…

Our second book is now available for pre-order. 🎉 Embracing the book's technology theme, we did something special: We encoded the entire book into DNA & packaged it into stainless steel capsules, where it will live for tens of thousands of years. 1,000 copies were made... 🧵

Thank you WIRED for the great article on our latest work with Asimov Press wired.com/story/entire-b…

Just in time for finals 🙇‍♂️: a bacterium designed to live in your gut and keep you performing well with little sleep. Rachel Hopton, Ph.D. Daniel Pascal Brandon Fields #microbiome #synbio #biotech #AirForce MIT Dept of BE Massachusetts Institute of Technology (MIT) pubs.acs.org/doi/full/10.10…

Phage-Assisted Evolution of Allosteric Protein Switches biorxiv.org/content/10.110… #biorxiv_synbio