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Bitter-sweet result. Our paper is out in Nature, but sometimes you're forced to hide your affiliation to make it happen. Viruses encode tRNAs to circumvent tRNA-targeting immune systems, like PARIS. Thanks to David Bikard, Wiedenheft Lab and the teams. nature.com/articles/s4158…

Really proud to see this work published -- a thrilling detective story I was lucky to be a part of. Big kudos to Stephen Tang and the entire team for an impressive collaborative effort. See Stephen's thread below to learn more... (and read the paper!). drive.google.com/file/d/1_paZuA…

Excited to introduce AntiDefenseFinder - a free, open source tool that detects anti-defense systems in any genomic sequence. Available here to toggle on/off: defensefinder.mdmlab.fr. Read below for our insights into the >47K detectable systems📈 tiny.cc/8xrizz

It was fun to bring together this special issue as editor with Rob Lavigne! Lucky to be part of a research community "...driven by curiosity and fellowships of phage researchers looking for someone to share in an adventure." sciencedirect.com/special-issue/… New Concepts in Prokaryotic Virus-Host Interaction

We are happy to share our recent preprint on (first ever CRISPR paper in my life😅): "CRISPR/dCas-mediated counter-silencing – Reprogramming dCas proteins into antagonists of xenogeneic silencers" #CRISPRcosi 🧵(1/8) biorxiv.org/content/10.110… Forschungszentrum Jülich | @[email protected], Heinrich-Heine-Universität Düsseldorf, MibiNet

No one: Absolutely no one: French medical textbook: hey here is a mnemonic to help you remember complications of obesity : "fat sow"

Almost two years ago I joined MDMLab and Poirier Lab to study the conservation of immunity between prokaryotes and eukaryotes, and our paper is out! While I didn't move country between PhD lab and postdoc lab, I did move from a bacteria-focused lab (hi @epcrocha ) to...

In a new study, we report the discovery of a human homolog of SIR2 antiphage proteins that participates in the TLR pathway of mammalian innate immunity!! Co-led with @EnzoZ_P lab, in collab with @morehouse_ben biorxiv.org/content/10.110…

Our paper out today @nature: phages reconstitute NAD+ to counter bacterial immunity Phaged invented a new biochemical pathway for NAD+ synthesis - including previously unknown enzymatic reactions - to evade bacterial defenses Congrats Ilya Osterman! nature.com/articles/s4158…

Are you planning to visit Ukraine soon? Or would you like to show your support and learn a little Ukrainian? Check out this short glossary of the most useful words and phrases. 🧵(1/10)

You are looking for a PostDoc position or know someone who is? We are looking for someone to join our team at ETH Zurich Zürich for a project on phage-host interactions of Pseudomonas aeruginosa 🦠🧬👇🏼

What kind of childhood makes a top scientist? Is it enough to have all the right traits (brilliance, grit, etc) or do you need the right family too? And why should we care? A 🧵 on our paper on the Nobel Laureates. A teaser: the income distribution of the laureates' fathers.1/N

Exciting and fantastic work - the new peak of recent studies reminding us that viruses are not the only mobile elements with their own evolutionary agenda! 🧬💪🏼👇🏼

🦠🧬Our paper is live Cell: Genome integrity sensing by the broad-spectrum Hachiman antiphage defense complex authors.elsevier.com/sd/article/S00… Through structural, genetic and microbiological approaches, we show that Hachiman degrades DNA… by sensing low integrity DNA.

This Is Spectacular

Fancy a postdoc in Munich? For a collaborative project between Sorek Lab and HornungLab on antiviral innate immunity, we are looking for exceptional candidates with skills in immunology / biochemistry / computational biology. More details here: genzentrum.uni-muenchen.de/career/postdoc…

Published today Nature Communications We discovered a bacterial NLR-like pattern recognition receptor that can sense 3 different viral proteins as a signature for infection. This explains its broad defense against different phage families Congrats Nathalie Bechon! nature.com/articles/s4146…

We shouldn't be afraid of Russia ☢️🇷🇺☢️ What many failed to understand is that Putin is not crazy nor stupid. He is even quite clever. He understood we are weak. He understood we are afraid by his power. We shouldn't. 🧵THREAD🧵1/25 ⬇️

It is finally out! Muntathar Al-Shimary, Doudna Lab, Brady Cress and I present a gene knockdown tool that works in diverse phages: CRISPRi through antisense RNA Targeting (CRISPRi-ART)! Check out the final paper in Nature Microbiology nature.com/articles/s4156…