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Today is Neuropathology Day! 🧠 We celebrated by hosting Dr. Caterina Giannini, MD, PhD who gave a talk at our Monday Seminar titled: Integrated diagnosis of primary CNS tumors. Here are some pictures from the day ⬇ #uoftmedicine #neuropathology #neuropathologyday

I have been in history for thousands of years but surprisingly not highly contagious I can be found in granulomas and like to go to the nerves I can be sub classified into pauci or multi Who am I +what is the stain⬇️? #path4people #pathagonia #micro #pathx #medx #microx

Online First: The landscape of primary mismatch repair deficient (dMMR) #gliomas in children, adolescents, and young adults: a multi-cohort study #childhoodcancer #AYAcancer thelancet.com/journals/lanon…

Excited to share two back-to-back papers recently published in SNO, with co-author @justinzwang We present new validated #precision #medicine tools for patients with #meningioma academic.oup.com/neuro-oncology… academic.oup.com/neuro-oncology… Read below for details

New work just published in SNO where we explore the #metabolic dependencies of #meningioma molecular groups, generating new biologic insights and #biomarkers for clinical care doi.org/10.1093/neuonc…

Dr. Zadeh delivered an outstanding lecture as their Dorothy Klenke Nash Lecturer at UPMC, presenting her work on advancing the understanding of meningiomas. A real tour de force in neuro-oncology and skull base gelareh-zadeh Mayo Clinic Neuro UPMC Costas Hadjipanayis Robert Friedlander

Teenage male with normal developmental milestones but difficulty playing sports or running. What is the diagnosis? Check the thread for more diagnostic images 👇 #pathtwitter #pathx #neuromuscularpath #neuropath #neuronotes

Our new paper is out today in JAMA Oncology demonstrating the importance of chromosome 1p loss and 1q gain in #meningioma grading jamanetwork.com/journals/jamao… Justin Z. Wang gelareh-zadeh Farshad Nassiri

Our new paper in JAMA Oncology demonstrating how #cytogenetics can inform #classification of #meningiomas in clinical practice Led by Alex Landry Justin Z. Wang University of Toronto Neurosurgery UHN Research University Health Network gelareh-zadeh Mayo Clinic Neuro Kenneth Aldape, MD + many more International Consortium on Meningiomas (ICOM) collaborators

Now online! Autoimmune mechanisms elucidated through muscle acetylcholine receptor structures dlvr.it/TK72F9

Intramedullary spinal tumor in a young woman. FISH showed apparent 1p/19q codeletion. Other molecular findings include BRAF fusion. Diagnosis? (You don't need to consult the Division for Lizard Governance and New Taxes to get this one right.😁) #pathology #neuropath #pathtwitter

This new report by several ICOM authors in JAMA Oncology highlights the importance of a role for #CytogeneticProfiling in the next iteration of #CNS WHO grading. Read now: jamanetwork.com/journals/jamao… Alex Landry Farshad Nassiri Justin Z. Wang gelareh-zadeh Kenneth Aldape, MD Sahm Lab Andrew Gao

Diffuse astrocytoma, MYB or MYBL1-altered. An infiltrating, but grade 1 glioma! (Note the trapped neurons—evidence of infiltration) Tumor cells rel. monomorphic, round to ovoid or spindly. It is strongly associated with epilepsy. #neuropath #neuropathology #pathx #PathTwitter

This 40-year-old patient has increasing back pain and lower extremity paraparesis. MRI of the cervical and lumbar spine with and without contrast showed multiple intradural leptomeningeal enhancing masses (spinal dissemination) with compression of the conus medullaris region.

New in Nature Cancer: CANON co-lead Dr. Julie Bennett and team show that 31% of AYA gliomas carry pediatric-type alterations. Findings highlight the need for age-specific approaches to diagnosis and treatment. nature.com/articles/s4301…

Excited to share our first lab paper, now published in Developmental Cell! 🧠 How do glioblastoma (GBM) cells invade the brain, and what enables them to spread so effectively?

UHN marks the passing of Dr. James Till, whose work with Dr. Ernest McCulloch first demonstrated the existence of blood-forming stem cells in 1961 at Ontario Cancer Institute, now Princess Margaret Cancer Centre. His work has helped launch the field of #stemcell science.

cIMPACT-NOW update 10: Recommendations for defining new types for central nervous system tumor classification #neuropath Kenneth Aldape, MD Sahm Lab Hawkins Lab onlinelibrary.wiley.com/doi/10.1111/bp…

This cohort study suggests that chromosomal alterations should be included in the WHO grading criteria for meningiomas, as they are associated with worse outcomes and can refine the current classification system. ja.ma/44mXMC4 Alireza Mansouri Andrew Gao