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Study categorisation from Stuart Pocock at #PratoAnaes2022 ➡️ WOW! and PHEW! interpreted the same but very different ➡️ PHEW! and DAMN! interpreted differently but virtually the same We need to get wiser, a p-value is no substitute for brain.

(1/10) Today the long-awaited full results from the Phase 3 ATTRibute-CM trial were presented European Society of Cardiology #ESCCongress. We already knew the topline results from last month: Acoramidis made a (big) difference in outcomes! What more did we learn?🤔Let's dig deeper...

1/18 🤔Why don't we use immunosuppression after bioprosthetic valve replacement? Not only is the graft not self, but most aren't even from the same species and instead are from cows or pigs. But unlike other transplants, we forego immunosuppression. Why? Let's have a look.

🧵New reference values for longitudinal strain from the HUNT4 study, measured by 2D ST from one vendor, but comparing varieties of the proprietary analysis software with different automation (2DS vs AFI) shows small differences. sciencedirect.com/science/articl…

Excited to see this study presented at #AHA23 Should every patient with CAD get a #WhyCMR to assess if it’s an ischemic CM or NICM? 1/6 pts will have either CAD+NICM or dual CM(ICM & NICM)with⬆️ risk ☠️or HF🏥but may🚫 benefit from revascularization bit.ly/471DdtV 📝

CMS pauses Appropriate Use Criteria (AUC) program for Advanced Diagnostic Imaging "an extraordinary number of inappropriately denied claims for advanced diagnostic imaging would result if the AUC program were implemented" acc.org/Latest-in-Card…

Diagnostic accuracy of ischemic ECG Stress testing to detect coronary microvascular dysfunction: ECG had 100% specificity for detection of microvascular dysfunction (defined as CFR<2.5 and/or Positive ACh challenge at invasive functional testing) jacc.org/doi/10.1016/j.…

The non-coding RNA revolution "Only 1-2% percent of RNA from our genome encodes proteins. What is the rest for?" "This is a far cry from the 70 year old basic narrative of biology, which was all about DNA leading to proteins" #MedTwitter #CardioTwitter scientificamerican.com/article/revolu…

How is a genetic variant (eg, a single-nucleotide polymorphism) directly associated with muesli intake?

Today, RGC has published an important paper in nature today, describing an analysis of close to a million human exomes (n=983,578) as a single variant call set (!). This is the largest and most diverse rare variant database created so far. This impressive feat is accomplished by

Ok this clip about navigating the American Healthcare System from the recent South Park ozempic special (which was brilliant) needs to be the opening of every healthcare conference panel

5 genes associated with dilated cardiomyopathy for the general cardiologist to be aware of - slide by Anshuman Sengupta at #bcs2024

Do GLP-1 agonists make you eat more healthy foods? Slide from Morgan Stanley shown by Dr John Deanfield UCL Royal Brompton and Harefield grand rounds #MedTwitter #CardioTwitter #GLP1 #obesity

The chance that this kind of arbitrary cluster analysis actually yields new clinical insights is next to nothing …

The Venetian method for electing a Doge was literally insane, or genius

In long term follow-up of the SPINS registry "peri-infarct ischemia" assessed by stress perfusion CMR may have independent prognostic value: jacc.org/doi/10.1016/j.… With accompanying editorial: jacc.org/doi/10.1016/j.… Raymond Kwong Sven Plein

1/ A recap of what is happening with $ALNY with regard to ATTR-CM data updates. June 24, 2024: focused on initial HELIOS-B Ph3 data - all endpts met, preparing to file. August 30, 2024: today the company shares the DETAILS of that data, presented at the European Society of

🔥🔥 Hot off the press 🔥🔥 #Strain in primary #MR with #WhyCMR ➡️ GLS may serve as a marker of cardiac dysfunction in primary MR patients with preserved #LVEF allowing identification of patients likely to decompensate during observation ➡️ academic.oup.com/ehjcimaging/ad… European Society of Cardiology Journals

New blog article challenging medical researchers who are drawn to clustering patients to create so-called "phenotypes" to think again: fharrell.com/post/cluster Maarten van Smeden “Darren Dahley” #Statistics #PrecisionMedicine @vandy_biostat