Want to use a cardiovascular disease🫀risk score for primary prevention, but unsure which is the best for your population?🧐 Our work compares CVD risk scores & provides a framework for selecting the most appropriate score. Just out in The Lancet Global Health!👀⬇️ doi.org/10.1016/S2214-…

In a preprint from the 23andMe Research team, we used Mendelian randomization to explore the genetically-predicted causal effects of Lp(a) on a range (n=489) of human traits and diseases. medrxiv.org/content/10.110…

Excited to share our latest paper, where we describe ITSN1 as a novel risk gene for Parkinson's disease! We found that rare loss-of-function variants are associated with a 10-fold increased odds of PD. As far as we know, this is the largest effect size reported for sporadic PD

Metabolic reaction fluxes as amplifiers and buffers of risk alleles for coronary artery disease medrxiv.org/cgi/content/sh… #medRxiv

Are you a Health Data Scientist looking to teach the next generation? The DPHPC MRC Biostatistics Unit MRC Epidemiology Unit MPhil Population Health Sciences is looking for a Senior Teaching Associate to contribute to the course! 🔗: jobs.cam.ac.uk/job/47728/ cc: Health Data Research UK (HDR UK) Cambridge

Check our paper in nature nature.com/articles/s4158… This is a huge collaborative work combining great basic and clinical science, with important implications for the prevention of atherosclerotic cardiovascular disease. Thanks to all our collaborators and funders!

Interested in a 4-year PhD studying the genetics of BMI and comorbidities? Don't wait, apply for my AstraZeneca-funded studentship w/ Xiao JIANG 🔗: jobs.cam.ac.uk/job/48333/ (due October 31)! BHF Cardiovascular Epidemiology Unit at Cambridge VPD Heart & Lung Research Institute CambridgeCardio DPHPC CambridgeATS

The Open Targets Platform autumn release 🍁 is full of new data and UI features. This is the last update before we make a giant leap forward in our common genetic evidence 🧬

🚨🚨New paper alert 🚨🚨 nature.com/articles/s4225… rdcu.be/dVak3

GWAS for Nobel prize laureates.

Delighted to see this out nature.com/articles/s4146… in Nature Communications - we ran GWAS of 42 quantitative blood test traits in up to 40k British South Asian @GenesHealth participants. You can our findings using the browser benjacobs.shinyapps.io/gh_quant_trait… Code: github.com/benjacobs12345…

Out in Nature Communications! Abdominal aortic aneurysm is a serious condition where the abdominal aorta enlarges & can rupture CEU colleagues used a polygenic risk score (PRS) to investigate the genetic risk & if you can use PRS to inform age for screening 🔗 tinyurl.com/mr3mupbc

What geneticists fear the most: The Cambridge Plot.

📢Fully-funded PhD studying the comorbidities of high adiposity. 🔗: jobs.cam.ac.uk/job/48333/ (2 weeks left, due November 20) Great work environment BHF Cardiovascular Epidemiology Unit at Cambridge VPD Heart & Lung Research Institute, collab with AstraZeneca Xiao JIANG CambridgeATS. DM or e-mail for informal enquiries.

🚨We're recruiting! Interested in making science and computing more environmentally friendly? Now is the time! Very excited to build a research group at Cambridge University to expand our Green Algorithms work thanks to the support of the Wellcome green-algorithms.org/join-us/

Excited for your return to Cambridge Kim!

Can genetics affect our iron levels and what impact can this have on our health? Elias Allara and colleagues explored how the body controls iron and highlight how having too much or too little can negatively impact health Read more here 👉 tinyurl.com/h5yk3sfb

What risk factors are associated with premature heart attack in Bangladesh? Our case-control study with 8133 Bangladeshi patients found many local risk factors, interestingly risk was highest with the local practices of tobacco consumption 🔗Read more here tinyurl.com/yz6repy9

Excited to share our latent factor approach for high-dimensional trait #GWAS + #finemapping out in Cell Genomics doi.org/10.1016/j.xgen… Uses summary-level data. Software: github.com/jennasimit/fla… Feng Zhou William Astle Adam Butterworth MRC Biostatistics Unit BHF Cardiovascular Epidemiology Unit at Cambridge

We are presenting our protein QTLs discoveries at #ESHG2025 #Poster P18.004.C. | May 26 | 1:00PM This project is led by a our great team manager Solène Cadiou at Human Technopole in collaboration with Cambridge Univ. and Biomedicine - Eurac Research